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Tdark
PCP2
Purkinje cell protein 2 homolog

Protein Summary
Description
May function as a cell-type specific modulator for G protein-mediated cell signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311069
  • ENSP00000310585
  • ENSG00000174788
  • ENST00000598935
  • ENSP00000472761

Symbol
  • GPSM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
cell type or tissue
0.63
gene perturbation
0.58
tissue sample
0.51
disease
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (257)
CST9
Tbio
Novelty:  0.08129086
p_int:  0.98617443
p_ni:  0.013573621
p_wrong:  0.000251949
Score:  0.332
Data Source:  BioPlex,STRINGDB
TMEM38A
Tbio
Family:  IC
Novelty:  0.10891929
p_int:  0.97516191
p_ni:  0.004600961
p_wrong:  0.020237129
Score:  0.513
Data Source:  BioPlex,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.957091215
p_ni:  0.042903773
p_wrong:  0.000005012
Score:  0.177
Data Source:  BioPlex,STRINGDB
CENPM
Tbio
Novelty:  0.0671332
p_int:  0.953800799
p_ni:  0.038680862
p_wrong:  0.007518339
Score:  0.29
Data Source:  BioPlex,STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
p_int:  0.953800799
p_ni:  0.038680862
p_wrong:  0.007518339
Score:  0.243
Data Source:  BioPlex,STRINGDB
RNASE2
Tchem
Family:  Enzyme
Novelty:  0.00267471
p_int:  0.930726151
p_ni:  0.06868379
p_wrong:  0.000590059
Score:  0.534
Data Source:  BioPlex,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.758467952
p_ni:  0.241532048
Score:  0.94
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.966
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.952
Data Source:  STRINGDB
GRM6
Tchem
Family:  GPCR
Novelty:  0.00681104
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
1
2
0
6.2
96.9
blood protein measurement
1
2
2
82.2
CD209 antigen measurement
2
2
2
76.5
low affinity immunoglobulin epsilon Fc receptor measurement
1
1
1
50.5
neuropathic pain
1
1
0
1.7
16.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
0
6.2
96.9
blood protein measurement
2
82.2
CD209 antigen measurement
2
76.5
low affinity immunoglobulin epsilon Fc receptor measurement
1
50.5
neuropathic pain
0
1.7
16.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Purkinje cell protein 2
VGNC:14865
742010
Macaque
Purkinje cell protein 2
704228
Mouse
MGI:97508
18545
Rat
RGD:1306217
304195
Dog
Purkinje cell protein 2
VGNC:44318
484996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Purkinje cell protein 2
Macaque
Purkinje cell protein 2
Mouse
Rat
Dog
Purkinje cell protein 2
Publication Statistics
PubMed Score 21.20
PubMed score by year
PubTator Score 33.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title