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Tbio
PCOLCE2
Procollagen C-endopeptidase enhancer 2

Protein Summary
Description
Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295992
  • ENSP00000295992
  • ENSG00000163710

Symbol
  • PCPE2
  • PCPE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
gene perturbation
0.83
histone modification site profile
0.75
transcription factor perturbation
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
OS9
Tbio
Novelty:  0.01490339
p_int:  0.996739377
p_ni:  0.003260338
p_wrong:  2.85e-7
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.99613032
p_ni:  0.003749941
p_wrong:  0.000119739
Data Source:  BioPlex
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
p_int:  0.994021496
p_ni:  0.0052559
p_wrong:  0.000722604
Data Source:  BioPlex
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.986319526
p_ni:  0.013443649
p_wrong:  0.000236825
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.9743252
p_ni:  0.025487738
p_wrong:  0.000187063
Data Source:  BioPlex
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
p_int:  0.96433163
p_ni:  0.03548892
p_wrong:  0.00017945
Score:  0.23
Data Source:  BioPlex,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.895580916
p_ni:  0.104419084
Score:  0.183
Data Source:  BioPlex,STRINGDB
OLFM1
Tbio
Novelty:  0.02210029
p_int:  0.854301869
p_ni:  0.003652136
p_wrong:  0.142045995
Score:  0.336
Data Source:  BioPlex,STRINGDB
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.813457728
p_ni:  0.002068156
p_wrong:  0.184474116
Data Source:  BioPlex
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
3
73
triglyceride measurement
4
4
4
66.3
red blood cell distribution width
2
2
2
64.4
heel bone mineral density
2
2
2
45.5
creatinine measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
73
triglyceride measurement
4
66.3
red blood cell distribution width
2
64.4
heel bone mineral density
2
45.5
creatinine measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
procollagen C-endopeptidase enhancer 2
VGNC:7080
460748
Macaque
procollagen C-endopeptidase enhancer 2
714225
Mouse
MGI:1923727
76477
Rat
RGD:1595195
684050
Dog
procollagen C-endopeptidase enhancer 2
VGNC:44317
477102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
procollagen C-endopeptidase enhancer 2
Macaque
procollagen C-endopeptidase enhancer 2
Mouse
Rat
Dog
procollagen C-endopeptidase enhancer 2
Publication Statistics
PubMed Score 9.12
PubMed score by year
PubTator Score 8.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title