Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

PCNX3

Ensembl ID

ENST00000355703
ENSP00000347931
ENSG00000197136

Symbol

PCNXL3
PCNXL3

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 10 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 10 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

See Interactions on String-DB

TM2D1

Tdark

Novelty: 0.1760181

p_int: 0.999982917

p_ni: 0.000017076

p_wrong: 7e-9

Data Source: BioPlex

FAM189A2

Tdark

Novelty: 0.41335428

p_int: 0.999415175

p_ni: 0.000584825

p_wrong: 1e-9

Data Source: BioPlex

TMEM31

Tdark

Novelty: 0.65381391

p_int: 0.999188675

p_ni: 0.000811324

p_wrong: 1e-9

Data Source: BioPlex

ZNRF4

Tbio

Novelty: 0.16505328

p_int: 0.997680565

p_ni: 0.002319435

Data Source: BioPlex

RXFP1

Tchem

Family: GPCR

Novelty: 0.00580827

p_int: 0.9926367

p_ni: 0.007363291

p_wrong: 9e-9

Data Source: BioPlex

RNF185

Tbio

Family: Enzyme

Novelty: 0.23911257

p_int: 0.991667964

p_ni: 0.008332036

Score: 0.175

Data Source: BioPlex,STRINGDB

SLC13A2

Tbio

Family: Transporter

Novelty: 0.01020451

p_int: 0.984708414

p_ni: 0.015291585

Score: 0.185

Data Source: BioPlex,STRINGDB

SLC4A8

Tbio

Family: Transporter

Novelty: 0.01606111

p_int: 0.982407313

p_ni: 0.017592681

p_wrong: 6e-9

Data Source: BioPlex

CHRNB1

Tclin

Family: IC

Novelty: 0.04777051

p_int: 0.975529105

p_ni: 0.024443298

p_wrong: 0.000027597

Data Source: BioPlex

YIPF3

Tbio

Novelty: 0.12021667

p_int: 0.960657186

p_ni: 0.039342814

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (48)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 48

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	4	4	5	97.8

heel bone mineral density	EFO_0009270	3	6	8	95.7

urate measurement	EFO_0004531	3	4	4	94

mean platelet volume	EFO_0004584	3	2	3	93.2

glomerular filtration rate	EFO_0005208	2	3	3	91.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 48

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	5	97.8

heel bone mineral density	EFO_0009270	8	95.7

urate measurement	EFO_0004531	4	94

mean platelet volume	EFO_0004584	3	93.2

glomerular filtration rate	EFO_0005208	3	91.9

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Alternative splicing

Complete proteome

Glycoprotein

Membrane

Phosphoprotein

Polymorphism

Reference proteome

Transmembrane

Transmembrane helix

GWAS Trait

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No Header	No Header
acne

age at onset

Agents acting on the renin-angiotensin system use measurement

albumin:globulin ratio measurement

alkaline phosphatase measurement

balding measurement

BMI-adjusted hip circumference

BMI-adjusted waist circumference

BMI-adjusted waist-hip ratio

body height

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID
Chimp	pecanex homolog 3	VGNC:6697	100612133

Mouse	pecanex homolog 3	MGI:1861733	104401

Rat	pecanex homolog 3	RGD:1305529	309167

Dog	pecanex homolog 3	VGNC:44314	483731

Horse	pecanex homolog 3	VGNC:21210	100057407

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pecanex homolog 3

Mouse	pecanex homolog 3

Rat	pecanex homolog 3

Dog	pecanex homolog 3

Horse	pecanex homolog 3

Publication Statistics

PubMed Score 0.96

PubMed score by year

PubTator Score 0.09

PubTator score by year

Related Publications

Text Mined References (5)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title