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Tbio
PCM1
Pericentriolar material 1 protein

Protein Summary
Description
Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310). The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [ ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
drug perturbation
0.99
ligand (protein) perturbation
0.99
co-expressed gene
0.98
disease perturbation
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999994513
p_ni:  0.000005487
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999993778
p_ni:  0.000006222
Data Source:  BioPlex
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.99997827
p_ni:  0.00002173
Score:  0.198
Data Source:  BioPlex,STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
p_int:  0.999915824
p_ni:  0.000083818
p_wrong:  3.57e-7
Score:  0.901
Data Source:  BioPlex,STRINGDB
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.999890454
p_ni:  0.000109546
Score:  0.154
Data Source:  BioPlex,STRINGDB
C6orf118
Tdark
Novelty:  4.32054176
p_int:  0.999884217
p_ni:  0.000115783
Score:  0.19
Data Source:  BioPlex,STRINGDB
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.999874192
p_ni:  0.000125808
Data Source:  BioPlex
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999824872
p_ni:  0.000175128
Data Source:  BioPlex
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999693642
p_ni:  0.000306358
Data Source:  BioPlex
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999673395
p_ni:  0.000326605
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
73.9
triglyceride measurement
1
1
1
38.8
1
1
0
1.1
33.1
mean reticulocyte volume
1
1
1
31.4
mean corpuscular volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
73.9
triglyceride measurement
1
38.8
0
1.1
33.1
mean reticulocyte volume
1
31.4
mean corpuscular volume
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pericentriolar material 1
VGNC:824
464020
Macaque
pericentriolar material 1
703580
Mouse
MGI:1277958
18536
Rat
RGD:620901
81740
Dog
pericentriolar material 1
VGNC:44309
475618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pericentriolar material 1
Macaque
pericentriolar material 1
Mouse
Rat
Dog
pericentriolar material 1
Publication Statistics
PubMed Score 36.80
PubMed score by year
PubTator Score 76.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title