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Tbio
PCLO
Protein piccolo

Protein Summary
Description
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333891
  • ENSP00000334319
  • ENSG00000186472
  • ENST00000423517
  • ENSP00000388393
  • ENST00000618073
  • ENSP00000482390

Symbol
  • ACZ
  • KIAA0559
  • ACZ
  • PCH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.96
kinase
0.94
cellular component
0.8
PubMedID
0.77
histone modification site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.87   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.87   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
RAPGEF4
Tchem
Novelty:  0.00235788
Score:  0.96
Data Source:  STRINGDB
RIMS2
Tbio
Novelty:  0.02785894
Score:  0.915
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.889
Data Source:  STRINGDB
RABAC1
Tbio
Novelty:  0.01749453
Score:  0.847
Data Source:  STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
Score:  0.755
Data Source:  STRINGDB
ERC2
Tbio
Novelty:  0.00953771
Score:  0.733
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.724
Data Source:  STRINGDB
ERC1
Tbio
Novelty:  0.01251
Score:  0.717
Data Source:  STRINGDB
TSEN54
Tbio
Family:  Enzyme
Novelty:  0.03157812
Score:  0.711
Data Source:  STRINGDB
UNC13A
Tbio
Novelty:  0.01009835
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1
75.4
3
3
1
3.6
53.7
3
3
1
3.5
53.7
major depressive disorder
2
1
1
6.1
45.2
1
1
0
6.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
75.4
1
3.6
53.7
1
3.5
53.7
major depressive disorder
1
6.1
45.2
0
6.1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piccolo presynaptic cytomatrix protein
VGNC:4458
463505
Mouse
MGI:1349390
26875
Rat
RGD:69406
56768
Dog
piccolo presynaptic cytomatrix protein [Source:HGNC Symbol;Acc:HGNC:13406]
Horse
piccolo presynaptic cytomatrix protein
VGNC:21205
100057788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piccolo presynaptic cytomatrix protein
Mouse
Rat
Dog
piccolo presynaptic cytomatrix protein [Source:HGNC Symbol;Acc:HGNC:13406]
Horse
piccolo presynaptic cytomatrix protein
Publication Statistics
PubMed Score 103.87
PubMed score by year
PubTator Score 20.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title