You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PCLAF
PCNA-associated factor

Protein Summary
Description
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300035
  • ENSP00000300035
  • ENSG00000166803
  • ENST00000380258
  • ENSP00000369608

Symbol
  • KIAA0101
  • NS5ATP9
  • PAF
  • L5
  • PAF
  • OEATC
  • PAF15
  • OEATC1
  • p15PAF
  • NS5ATP9
  • OEATC-1
  • p15/PAF
  • KIAA0101
  • p15(PAF)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.68   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.68   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0