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Tbio
PCK2
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Protein Summary
Description
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216780
  • ENSP00000216780
  • ENSG00000100889
  • ENST00000396973
  • ENSP00000380171
  • ENST00000545054
  • ENSP00000441826
  • ENST00000561286
  • ENSP00000454011
  • ENST00000644679
  • ENSP00000496102
  • ENSG00000285241
  • ENST00000645217
  • ENSP00000494919
  • ENST00000645536
  • ENSP00000496343
  • ENST00000645709
  • ENSP00000494029

Symbol
  • PEPCK2
  • PEPCK
  • PEPCK2
  • PEPCK-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.93
transcription factor perturbation
0.88
biological process
0.8
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.12   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.12   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0