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Tbio
PCGF3
Polycomb group RING finger protein 3

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362003
  • ENSP00000354724
  • ENSG00000185619
  • ENST00000470161
  • ENSP00000420489

Symbol
  • RNF3
  • RNF3A
  • RNF3
  • DONG1
  • RNF3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
microRNA
0.85
disease perturbation
0.83
cell type or tissue
0.76
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.53
Data Source:  BioPlex,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.904
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999912
p_ni:  6e-8
p_wrong:  2.8e-8
Score:  0.782
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999999472
p_ni:  4.86e-7
p_wrong:  4.2e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999996152
p_ni:  0.000003844
p_wrong:  5e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
CBX7
Tchem
Family:  Epigenetic
Novelty:  0.01612606
p_int:  0.99910239
p_ni:  0.000479685
p_wrong:  0.000417925
Score:  0.97
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.935999607
p_ni:  0.016108288
p_wrong:  0.047892105
Score:  0.712
Data Source:  BioPlex,STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.983
Data Source:  STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.972
Data Source:  STRINGDB
PHC2
Tbio
Novelty:  0.01943349
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
90.3
myeloid white cell count
2
2
2
89.7
monocyte percentage of leukocytes
2
2
2
89.5
leukocyte count
2
2
2
86.2
3
2
2
1.1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
90.3
myeloid white cell count
2
89.7
monocyte percentage of leukocytes
2
89.5
leukocyte count
2
86.2
2
1.1
83.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
polycomb group ring finger 3
697151
Mouse
MGI:1916837
69587
Rat
RGD:1311479
305624
Dog
polycomb group ring finger 3
VGNC:44302
612315
Horse
polycomb group ring finger 3
VGNC:21199
100051730
Species
Name
OMA
EggNOG
Inparanoid
Macaque
polycomb group ring finger 3
Mouse
Rat
Dog
polycomb group ring finger 3
Horse
polycomb group ring finger 3
Publication Statistics
PubMed Score 8.17
PubMed score by year
PubTator Score 3.96
PubTator score by year
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Related Publications
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PMID
Year
Title