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Tbio
PCGF2
Polycomb group RING finger protein 2

Protein Summary
Description
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). The protein encoded by this gene contai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610440
  • ENSP00000478517
  • ENSG00000278644
  • ENST00000611883
  • ENSP00000478970
  • ENSG00000277258
  • ENST00000616199
  • ENSP00000482063
  • ENST00000620225
  • ENSP00000482815
  • ENST00000631566
  • ENSP00000488872
  • ENST00000631610
  • ENSP00000488868

Symbol
  • MEL18
  • RNF110
  • ZNF144
  • TPFS
  • MEL-18
  • RNF110
  • ZNF144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
transcription factor binding site profile
0.84
disease perturbation
0.83
molecular function
0.7
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (190)
PHC1
Tbio
Novelty:  0.01530622
p_int:  1
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  1
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  1
Score:  0.857
Data Source:  BioPlex,STRINGDB
CBX8
Tchem
Family:  Epigenetic
Novelty:  0.00205993
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.987
Data Source:  BioPlex,STRINGDB
CBX2
Tchem
Family:  Epigenetic
Novelty:  0.01952928
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  4e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
SCMH1
Tbio
Family:  Epigenetic
Novelty:  0.14054708
p_int:  0.999999992
p_ni:  5e-9
p_wrong:  3e-9
Score:  0.792
Data Source:  BioPlex,STRINGDB
PHC3
Tbio
Novelty:  0.00091911
p_int:  0.99999999
p_ni:  1e-9
p_wrong:  9e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
PHC2
Tbio
Novelty:  0.01943349
p_int:  0.99999998
p_ni:  2e-8
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
CBX4
Tchem
Family:  Epigenetic
Novelty:  0.02681197
p_int:  0.999999807
p_ni:  1.77e-7
p_wrong:  1.6e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
BMI1
Tbio
Novelty:  0.00158043
p_int:  0.999999568
p_ni:  4.3e-7
p_wrong:  2e-9
Score:  0.942
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
FEV/FEC ratio
1
78.4
body height
2
68
body height
2
68
heel bone mineral density
2
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99161
22658
Rat
RGD:1305097
287662
Dog
polycomb group ring finger 2
VGNC:44301
491035
Horse
polycomb group ring finger 2
VGNC:21198
100055282
Cow
polycomb group ring finger 2
VGNC:32627
505147
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
polycomb group ring finger 2
Horse
polycomb group ring finger 2
Cow
polycomb group ring finger 2
Publication Statistics
PubMed Score 51.44
PubMed score by year
PubTator Score 40.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title