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Tbio
PCGF2
Polycomb group RING finger protein 2

Protein Summary
Description
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). The protein encoded by this gene contai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610440
  • ENSP00000478517
  • ENSG00000278644
  • ENST00000611883
  • ENSP00000478970
  • ENSG00000277258
  • ENST00000616199
  • ENSP00000482063
  • ENST00000620225
  • ENSP00000482815
  • ENST00000631566
  • ENSP00000488872
  • ENST00000631610
  • ENSP00000488868

Symbol
  • MEL18
  • RNF110
  • ZNF144
  • TPFS
  • MEL-18
  • RNF110
  • ZNF144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
transcription factor binding site profile
0.84
disease perturbation
0.83
molecular function
0.7
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.31   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.31   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0