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Tbio
PCDHGC3
Protocadherin gamma-C3

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308177
  • ENSP00000312070
  • ENSG00000240184
  • ENST00000611950
  • ENSP00000481219

Symbol
  • PCDH2
  • PC43
  • PCDH2
  • PCDH-GAMMA-C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
cell line
0.58
protein domain
0.58
transcription factor binding site profile
0.57
PubMedID
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
PCDHGB3
Tdark
Novelty:  1.9379995
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.576
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999999902
p_ni:  9.8e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
GRTP1
Tdark
Novelty:  0.8841166
p_int:  0.999942653
p_ni:  0.000057346
Score:  0.177
Data Source:  BioPlex,STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.999938912
p_ni:  0.000061088
Score:  0.171
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999806049
p_ni:  0.000193942
p_wrong:  1e-8
Data Source:  BioPlex
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.999493168
p_ni:  0.000506832
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.998741853
p_ni:  0.00125682
p_wrong:  0.000001327
Score:  0.161
Data Source:  BioPlex,STRINGDB
FLRT1
Tbio
Novelty:  0.23047852
p_int:  0.998423337
p_ni:  0.001576662
Score:  0.151
Data Source:  BioPlex,STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
p_int:  0.998061572
p_ni:  0.00000496
p_wrong:  0.001933468
Score:  0.283
Data Source:  BioPlex,STRINGDB
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.997858707
p_ni:  0.002141293
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
84.4
educational attainment
1
2
2
78.3
self reported educational attainment
2
2
2
65
allergic disease
1
1
0
1
56.6
triglyceride measurement
2
1
2
37
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
84.4
educational attainment
2
78.3
self reported educational attainment
2
65
allergic disease
0
1
56.6
triglyceride measurement
2
37
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 19.08
PubMed score by year
PubTator Score 4.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title