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Tdark
PCDHGA5
Protocadherin gamma-A5

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518069
  • ENSP00000429834
  • ENSG00000253485
  • ENST00000611914
  • ENSP00000480337

Symbol
  • ME3
  • CDH-GAMMA-A5
  • PCDH-GAMMA-A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.53
microRNA
0.5
pathway
0.47
tissue sample
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.44   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
PCDHGA9
Tdark
Novelty:  1.59893823
p_int:  1
Score:  0.176
Data Source:  BioPlex,STRINGDB
PLEKHG6
Tbio
Novelty:  0.15989022
p_int:  0.999999835
p_ni:  1.65e-7
Data Source:  BioPlex
PCDHGA6
Tdark
Novelty:  1.60910393
p_int:  0.999999811
p_ni:  1.4e-8
p_wrong:  1.75e-7
Data Source:  BioPlex
MLYCD
Tchem
Family:  Enzyme
Novelty:  0.01670441
p_int:  0.999999478
p_ni:  5.2e-7
p_wrong:  1e-9
Data Source:  BioPlex
PCDHGA7
Tdark
Novelty:  1.67766171
p_int:  0.999997345
p_ni:  1e-8
p_wrong:  0.000002646
Score:  0.178
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999966748
p_ni:  0.000033237
p_wrong:  1.5e-8
Data Source:  BioPlex
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
p_int:  0.999756494
p_ni:  0.000243506
Data Source:  BioPlex
PCDHGA8
Tdark
Novelty:  0.58754246
p_int:  0.999751258
p_wrong:  0.000248742
Score:  0.244
Data Source:  BioPlex,STRINGDB
AREL1
Tdark
Family:  Enzyme
Novelty:  0.31082841
p_int:  0.999086886
p_ni:  0.000716865
p_wrong:  0.000196249
Score:  0.152
Data Source:  BioPlex,STRINGDB
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.998541904
p_ni:  0.001458096
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
6
93.5
self reported educational attainment
2
2
2
57.1
triglyceride measurement
1
1
1
47.7
1
1
0
1
46.5
age at first birth measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
93.5
self reported educational attainment
2
57.1
triglyceride measurement
1
47.7
0
1
46.5
age at first birth measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.44
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title