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Tdark
PCDHB16
Protocadherin beta-16

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000609684
  • ENSP00000477314
  • ENSG00000272674

Symbol
  • KIAA1621
  • PCDH3X
  • ME1
  • PCDH3X
  • PCDHB8a
  • PCDH-BETA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
microRNA
0.79
protein domain
0.58
pathway
0.47
tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
PCDHB10
Tdark
Novelty:  0.52155812
p_int:  1
Score:  0.273
Data Source:  BioPlex,STRINGDB
PCDHB3
Tdark
Novelty:  0.51391546
p_int:  0.999999986
p_wrong:  1.4e-8
Data Source:  BioPlex
PCDHB7
Tdark
Novelty:  0.60789936
p_int:  0.999999966
p_wrong:  3.4e-8
Score:  0.68
Data Source:  BioPlex,STRINGDB
PCDHB6
Tdark
Novelty:  0.87147533
p_int:  0.999999612
p_ni:  1e-9
p_wrong:  3.86e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
GAST
Tbio
Novelty:  0.00011795
p_int:  0.99997316
p_ni:  0.000026764
p_wrong:  7.6e-8
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999894804
p_ni:  0.000001279
p_wrong:  0.000103918
Score:  0.2
Data Source:  BioPlex,STRINGDB
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
p_int:  0.999043773
p_ni:  0.000689544
p_wrong:  0.000266682
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.998995161
p_ni:  0.001004839
Data Source:  BioPlex
TAOK2
Tchem
Family:  Kinase
Novelty:  0.0232708
p_int:  0.997371291
p_ni:  0.002628708
p_wrong:  1e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.997143134
p_ni:  1.89e-7
p_wrong:  0.002856676
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
38.8
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 16
462133
Mouse
MGI:2136754
93888
Cow
protocadherin beta-16
100848138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 16
Mouse
Cow
protocadherin beta-16
Publication Statistics
PubMed Score 1.61
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title