Protein Summary
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
- ENST00000354757
- ENSP00000346802
- ENSG00000197479
- ENST00000624887
- ENSP00000485553
- ME2
- PCDH-BETA11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
cell type or tissue | 0.76 | ||
microRNA | 0.65 | ||
PubMedID | 0.62 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.33 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.33 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
TMTC2
Novelty: 0.17232458
p_int: 0.999999095
p_ni: 6.07e-7
p_wrong: 2.98e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
SPECC1
Novelty: 0.00830299
p_int: 0.999890174
p_ni: 0.000109741
p_wrong: 8.5e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
LTBP1
Novelty: 0.00958396
p_int: 0.999522549
p_ni: 0.00047745
p_wrong: 1e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
VWA1
Novelty: 0.00212445
p_int: 0.998965965
p_ni: 0.00103401
p_wrong: 2.5e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
DCBLD2
Novelty: 0.06514947
p_int: 0.998962054
p_ni: 0.001037926
p_wrong: 2e-8
Data Source: BioPlex
ST7L
Novelty: 0.03661324
p_int: 0.99728934
p_ni: 0.002710566
p_wrong: 9.4e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 38.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protocadherin beta 11 | 737812 | ||||||
Pig | protocadherin beta-11-like | 100737316 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protocadherin beta 11 | |||||
Pig | protocadherin beta-11-like | |||||
Publication Statistics
PubMed Score 1.33
PubMed score by year
PubTator Score 1.20
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|