Protein Summary
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
- ENST00000306549
- ENSP00000307234
- ENSG00000171815
- PCDH-BETA1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
cell type or tissue | 0.88 | ||
protein domain | 0.58 | ||
tissue sample | 0.58 | ||
cell line | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.86 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 83 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.86 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 83 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
EDA
Novelty: 0.00352464
p_int: 0.998196662
p_ni: 0.001090202
p_wrong: 0.000713136
Data Source: BioPlex
RDH13
Family: Enzyme
Novelty: 0.20184998
p_int: 0.997682264
p_ni: 0.002317736
Data Source: BioPlex
CTAGE5
Novelty: 0.04516631
p_int: 0.997593067
p_ni: 0.00240693
p_wrong: 3e-9
Data Source: BioPlex
PCDHGB6
Novelty: 0.24813852
p_int: 0.989625177
p_ni: 0.000035449
p_wrong: 0.010339375
Data Source: BioPlex
PTPRD
Family: Enzyme
Novelty: 0.01059407
p_int: 0.987815393
p_ni: 0.012184576
p_wrong: 3.1e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
LRP12
Novelty: 0.11426952
p_int: 0.953830506
p_ni: 0.045781676
p_wrong: 0.000387818
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protocadherin beta 1 | 471658 | ||||||
Macaque | protocadherin beta 1 | 699508 | ||||||
Mouse | MGI:2136730 | 93872 | ||||||
Rat | RGD:1308760 | 364841 | ||||||
Dog | protocadherin beta 1 | 487168 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protocadherin beta 1 | |||||
Macaque | protocadherin beta 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protocadherin beta 1 | |||||
Publication Statistics
PubMed Score 0.86
PubMed score by year
PubTator Score 0.64
PubTator score by year
Related Publications
Text Mined References (8)
Items per page:
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