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Tdark
PCDHB1
Protocadherin beta-1

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306549
  • ENSP00000307234
  • ENSG00000171815

Symbol
  • PCDH-BETA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
cell type or tissue
0.88
protein domain
0.58
tissue sample
0.58
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.86   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.86   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
EDA
Tbio
Novelty:  0.00352464
p_int:  0.998196662
p_ni:  0.001090202
p_wrong:  0.000713136
Data Source:  BioPlex
RDH13
Tbio
Family:  Enzyme
Novelty:  0.20184998
p_int:  0.997682264
p_ni:  0.002317736
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.997593067
p_ni:  0.00240693
p_wrong:  3e-9
Data Source:  BioPlex
PCDHGB6
Tdark
Novelty:  0.24813852
p_int:  0.989625177
p_ni:  0.000035449
p_wrong:  0.010339375
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.987815393
p_ni:  0.012184576
p_wrong:  3.1e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
TMTC3
Tdark
Novelty:  0.17411457
p_int:  0.970313498
p_ni:  0.029686502
Data Source:  BioPlex
LRP12
Tbio
Novelty:  0.11426952
p_int:  0.953830506
p_ni:  0.045781676
p_wrong:  0.000387818
Data Source:  BioPlex
ITGA6
Tbio
Novelty:  0.00217985
p_int:  0.951531444
p_ni:  0.048468556
Data Source:  BioPlex
LSR
Tbio
Novelty:  0.00528058
p_int:  0.915949013
p_ni:  0.084050987
Data Source:  BioPlex
GRAMD1A
Tbio
Novelty:  0.15461113
p_int:  0.890302937
p_ni:  0.109697063
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 1
471658
Macaque
protocadherin beta 1
699508
Mouse
MGI:2136730
93872
Rat
RGD:1308760
364841
Dog
protocadherin beta 1
487168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin beta 1
Macaque
protocadherin beta 1
Mouse
Rat
Dog
protocadherin beta 1
Publication Statistics
PubMed Score 0.86
PubMed score by year
PubTator Score 0.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title