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Tbio
PCDHAC2
Protocadherin alpha-C2

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critica ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289269
  • ENSP00000289269
  • ENSG00000243232
  • ENST00000615316
  • ENSP00000478629

Symbol
  • PCDH-ALPHA-C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.93
tissue sample
0.84
cell type or tissue
0.6
PubMedID
0.59
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999818296
p_ni:  0.000181704
Score:  0.153
Data Source:  BioPlex,STRINGDB
FRMD5
Tbio
Novelty:  0.34991399
p_int:  0.999815311
p_ni:  0.000184329
p_wrong:  3.6e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
RAB23
Tbio
Family:  Enzyme
Novelty:  0.01686155
p_int:  0.999787579
p_ni:  0.000210994
p_wrong:  0.000001428
Score:  0.173
Data Source:  BioPlex,STRINGDB
TMEM258
Tdark
Novelty:  0.22121107
p_int:  0.999703904
p_ni:  0.000005941
p_wrong:  0.000290155
Score:  0.188
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.998345729
p_ni:  0.001654258
p_wrong:  1.3e-8
Data Source:  BioPlex
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
p_int:  0.998034548
p_ni:  0.001965273
p_wrong:  1.8e-7
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.997989938
p_ni:  0.002004447
p_wrong:  0.000005615
Data Source:  BioPlex
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
p_int:  0.996819113
p_ni:  0.002260776
p_wrong:  0.000920111
Data Source:  BioPlex
CGRRF1
Tdark
Novelty:  0.49690187
p_int:  0.996611727
p_ni:  0.003384233
p_wrong:  0.00000404
Data Source:  BioPlex
ZDHHC18
Tdark
Family:  Enzyme
Novelty:  0.44878853
p_int:  0.993364168
p_ni:  0.00520927
p_wrong:  0.001426563
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sum of basophil and neutrophil counts
1
1
1
20.5
neutrophil count
1
1
1
20.5
educational attainment
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sum of basophil and neutrophil counts
1
20.5
neutrophil count
1
20.5
educational attainment
1
4.5
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Xenopus
protocadherin alpha subfamily C, 2
XB-GENE-1008093
100125023
Zebrafish
ZDB-GENE-041118-12
493587
Species
Name
OMA
EggNOG
Inparanoid
Xenopus
protocadherin alpha subfamily C, 2
Zebrafish
Publication Statistics
PubMed Score 5.48
PubMed score by year
PubTator Score 1.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title