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Tbio
PCDH8
Protocadherin-8

Protein Summary
Description
Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338862
  • ENSP00000341350
  • ENSG00000136099
  • ENST00000377942
  • ENSP00000367177

Symbol
  • PAPC
  • ARCADLIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.76
transcription factor binding site profile
0.69
cell type or tissue
0.64
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.5   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.5   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
PAPOLG
Tbio
Family:  Enzyme
Novelty:  0.02468251
Score:  0.798
Data Source:  STRINGDB
C3orf58
Tbio
Novelty:  0.03694539
Score:  0.712
Data Source:  STRINGDB
GSX1
Tbio
Family:  TF
Novelty:  0.01561622
Score:  0.658
Data Source:  STRINGDB
NAA16
Tbio
Family:  Enzyme
Novelty:  0.23261397
Score:  0.648
Data Source:  STRINGDB
HIVEP1
Tbio
Family:  TF
Novelty:  0.03053678
Score:  0.644
Data Source:  STRINGDB
KLHL1
Tbio
Novelty:  0.05206893
Score:  0.603
Data Source:  STRINGDB
IREB2
Tbio
Novelty:  0.00300491
Score:  0.574
Data Source:  STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.563
Data Source:  STRINGDB
RNF112
Tbio
Novelty:  0.00205441
Score:  0.555
Data Source:  STRINGDB
STX2
Tbio
Novelty:  0.00079512
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
p-tau measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
p-tau measurement
1
1.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin 8
VGNC:5090
452748
Macaque
protocadherin 8
694442
Mouse
MGI:1306800
18530
Rat
RGD:69350
64865
Dog
protocadherin-8
485469
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin 8
Macaque
protocadherin 8
Mouse
Rat
Dog
protocadherin-8
Publication Statistics
PubMed Score 103.50
PubMed score by year
PubTator Score 75.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title