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Tbio
PCDH17
Protocadherin-17

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377918
  • ENSP00000367151
  • ENSG00000118946
  • ENST00000484979
  • ENSP00000432899

Symbol
  • PCDH68
  • PCH68
  • PCH68
  • PCDH68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.89
PubMedID
0.86
transcription factor
0.68
transcription factor perturbation
0.68
histone modification site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.28   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.28   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999999557
p_ni:  4.43e-7
Data Source:  BioPlex
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.999997475
p_ni:  0.000002313
p_wrong:  2.12e-7
Score:  0.812
Data Source:  BioPlex,STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.999807679
p_ni:  0.000188131
p_wrong:  0.00000419
Score:  0.347
Data Source:  BioPlex,STRINGDB
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.999220516
p_ni:  0.000775488
p_wrong:  0.000003996
Score:  0.424
Data Source:  BioPlex,STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
p_int:  0.991269012
p_ni:  0.000388273
p_wrong:  0.008342715
Score:  0.823
Data Source:  BioPlex,STRINGDB
LSMEM2
Tdark
Novelty:  43
p_int:  0.817484313
p_ni:  0.000169934
p_wrong:  0.182345753
Data Source:  BioPlex
KCTD2
Tdark
Novelty:  0.42992811
Score:  0.684
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.677
Data Source:  STRINGDB
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
Score:  0.662
Data Source:  STRINGDB
TCTA
Tbio
Novelty:  0.05114911
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
4
4
3.9
96.5
intelligence
3
6
5
6.7
84.2
mathematical ability
2
2
2
80
1
1
1
64.9
C-reactive protein measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3.9
96.5
intelligence
5
6.7
84.2
mathematical ability
2
80
1
64.9
C-reactive protein measurement
1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protocadherin 17
VGNC:5089
467373
Macaque
protocadherin 17
695637
Mouse
MGI:2684924
219228
Rat
RGD:1304753
306055
Dog
protocadherin 17 [Source:HGNC Symbol;Acc:HGNC:14267]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protocadherin 17
Macaque
protocadherin 17
Mouse
Rat
Dog
protocadherin 17 [Source:HGNC Symbol;Acc:HGNC:14267]
Publication Statistics
PubMed Score 40.28
PubMed score by year
PubTator Score 23.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title