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Tbio
PCBP4
Poly(rC)-binding protein 4

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322099
  • ENSP00000322341
  • ENSG00000090097
  • ENST00000355852
  • ENSP00000348111
  • ENST00000428823
  • ENSP00000395030
  • ENST00000461554
  • ENSP00000417196
  • ENST00000484633
  • ENSP00000417100

Symbol
  • CBP
  • LIP4
  • MCG10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
transcription factor perturbation
0.8
transcription factor
0.75
histone modification site profile
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PPID
Tchem
Family:  Enzyme
Novelty:  0.01068886
p_int:  0.999721961
p_ni:  0.000278036
p_wrong:  3e-9
Score:  0.329
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.999497919
p_ni:  0.000502009
p_wrong:  7.2e-8
Data Source:  BioPlex
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.99933259
p_ni:  0.00066741
Score:  0.196
Data Source:  BioPlex,STRINGDB
CSPG4
Tbio
Novelty:  0.0038499
p_int:  0.998673224
p_ni:  0.000888796
p_wrong:  0.00043798
Score:  0.337
Data Source:  BioPlex,STRINGDB
TXNDC8
Tbio
Novelty:  0.15772943
p_int:  0.99499721
p_ni:  0.005002778
p_wrong:  1.2e-8
Data Source:  BioPlex
GTPBP10
Tbio
Novelty:  0.18563864
p_int:  0.99386973
p_ni:  0.006129603
p_wrong:  6.67e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
MIEN1
Tbio
Novelty:  0.02381294
p_int:  0.990567815
p_ni:  0.009432185
Data Source:  BioPlex
GTF2A2
Tbio
Novelty:  0.03391028
p_int:  0.989976642
p_ni:  0.010023353
p_wrong:  5e-9
Data Source:  BioPlex
SSR3
Tbio
Novelty:  0.05838475
p_int:  0.980872028
p_ni:  0.019127702
p_wrong:  2.7e-7
Data Source:  BioPlex
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.841948815
p_ni:  0.157994
p_wrong:  0.000057185
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell cycle genes
Reactome
G1/S DNA Damage Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
FOXO-mediated transcription
FOXO-mediated transcription of cell cycle genes
G1/S DNA Damage Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
macrophage inflammatory protein 1b measurement
1
1
1
33.1
urate measurement
1
1
1
12.2
high density lipoprotein cholesterol measurement
1
1
1
10.6
apolipoprotein A 1 measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
macrophage inflammatory protein 1b measurement
1
33.1
urate measurement
1
12.2
high density lipoprotein cholesterol measurement
1
10.6
apolipoprotein A 1 measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 4
VGNC:53378
460410
Macaque
poly(rC) binding protein 4
699225
Mouse
MGI:1890471
59092
Rat
RGD:1307910
363133
Dog
poly(rC) binding protein 4
476603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 4
Macaque
poly(rC) binding protein 4
Mouse
Rat
Dog
poly(rC) binding protein 4
Publication Statistics
PubMed Score 26.32
PubMed score by year
PubTator Score 19.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title