Tbio PCBP4 Poly(rC)-binding protein 4

Protein Summary

Description

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P57723
• Q96AH7

Gene Name

• PCBP4

Ensembl ID

• ENST00000322099
• ENSP00000322341
• ENSG00000090097
• ENST00000355852
• ENSP00000348111
• ENST00000428823
• ENSP00000395030
• ENST00000461554
• ENSP00000417196
• ENST00000484633
• ENSP00000417100

Symbol

• CBP
• LIP4
• MCG10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
transcription factor perturbation	0.8
transcription factor	0.75
histone modification site profile	0.66
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Poly(rc)-binding Protein 4

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Poly(rc)-binding Protein 4

Protein / Enzyme Modulator / Poly(rc)-binding Protein 4

Protein / ... / Serine Protease / Poly(rc)-binding Protein 4

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Poly(rc)-binding Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.85   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.85   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0