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Tbio
PCBP3
Poly(rC)-binding protein 3

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400308
  • ENSP00000383163
  • ENSG00000183570
  • ENST00000400309
  • ENSP00000383164
  • ENST00000400310
  • ENSP00000383165
  • ENST00000400314
  • ENSP00000383168

Symbol
  • PCBP3-OT1
  • PCBP3OT
  • PCBP3OT
  • ALPHA-CP3
  • PCBP3-OT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
co-expressed gene
0.98
disease perturbation
0.68
gene perturbation
0.63
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
HDAC10
Tclin
Family:  Epigenetic
Novelty:  0.00976829
p_int:  0.999645819
p_ni:  0.000354181
Score:  0.182
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.997926719
p_ni:  0.002032279
p_wrong:  0.000041002
Score:  0.282
Data Source:  BioPlex,STRINGDB
WNT16
Tbio
Novelty:  0.00966869
p_int:  0.997200768
p_ni:  0.002781195
p_wrong:  0.000018036
Score:  0.2
Data Source:  BioPlex,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.996318303
p_ni:  0.003681697
Data Source:  BioPlex
PDCD2L
Tbio
Novelty:  0.33193498
p_int:  0.996049605
p_ni:  0.003863022
p_wrong:  0.000087373
Score:  0.183
Data Source:  BioPlex,STRINGDB
RTL8B
Tdark
Novelty:  2.29599566
p_int:  0.993508753
p_ni:  0.006491202
p_wrong:  4.5e-8
Data Source:  BioPlex
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.989901565
p_ni:  0.010096134
p_wrong:  0.000002301
Data Source:  BioPlex
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.983873779
p_ni:  0.016126215
p_wrong:  5e-9
Data Source:  BioPlex
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
p_int:  0.979327792
p_ni:  0.015916685
p_wrong:  0.004755523
Score:  0.154
Data Source:  BioPlex,STRINGDB
MYBL1
Tbio
Family:  TF
Novelty:  0.00695014
p_int:  0.974897658
p_ni:  0.025102339
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal hysteresis
1
1
1
87.2
intraocular pressure measurement
2
3
3
83.7
refractive error measurement
2
2
1
7.7
63.6
Myopia
2
2
0
4.4
63.1
corneal resistance factor
2
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal hysteresis
1
87.2
intraocular pressure measurement
3
83.7
refractive error measurement
1
7.7
63.6
Myopia
0
4.4
63.1
corneal resistance factor
2
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 3
VGNC:3731
474053
Macaque
poly(rC) binding protein 3
709663
Mouse
MGI:1890470
59093
Rat
RGD:1307430
294336
Dog
poly(rC) binding protein 3
VGNC:53035
607066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 3
Macaque
poly(rC) binding protein 3
Mouse
Rat
Dog
poly(rC) binding protein 3
Publication Statistics
PubMed Score 8.65
PubMed score by year
PubTator Score 4.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title