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Tbio
PCBP1
Poly(rC)-binding protein 1

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been impl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303577
  • ENSP00000305556
  • ENSG00000169564

Symbol
  • HNRPX
  • HNRPE1
  • hnRNP-X
  • HEL-S-85
  • hnRNP-E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
protein complex
1
disease perturbation
0.98
transcription factor binding site profile
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.4   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.4   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (377)
FRK
Tchem
Family:  Kinase
Novelty:  0.00715757
p_int:  1
Score:  0.521
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.999991261
p_ni:  0.000008739
Data Source:  BioPlex
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.999983432
p_ni:  0.000016567
Score:  0.278
Data Source:  BioPlex,STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
p_int:  0.999880924
p_ni:  0.000119076
Score:  0.201
Data Source:  BioPlex,STRINGDB
MET
Tclin
Family:  Kinase
Novelty:  0.00037995
p_int:  0.998289355
p_ni:  0.000007336
p_wrong:  0.001703309
Score:  0.294
Data Source:  BioPlex,STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
p_int:  0.963635472
p_ni:  0.036364528
Score:  0.373
Data Source:  BioPlex,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
p_int:  0.959080933
p_ni:  0.040919067
Score:  0.238
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.919020572
p_ni:  0.080979428
Score:  0.267
Data Source:  BioPlex,STRINGDB
SETMAR
Tbio
Family:  Epigenetic
Novelty:  0.02859547
p_int:  0.884589714
p_ni:  0.115410286
Score:  0.273
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.882669131
p_ni:  0.117330869
Score:  0.439
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
78.6
leukocyte count
1
1
1
71.6
neutrophil count
2
2
2
68.5
red blood cell density measurement
1
1
1
61.4
mean reticulocyte volume
1
1
1
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
78.6
leukocyte count
1
71.6
neutrophil count
2
68.5
red blood cell density measurement
1
61.4
mean reticulocyte volume
1
30.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 1
VGNC:373
459300
Mouse
MGI:1345635
23983
Dog
poly(rC) binding protein 1
481417
Horse
poly(rC) binding protein 1
VGNC:51385
100050579
Cow
poly(rC) binding protein 1
509917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 1
Mouse
Dog
poly(rC) binding protein 1
Horse
poly(rC) binding protein 1
Cow
poly(rC) binding protein 1
Publication Statistics
PubMed Score 132.40
PubMed score by year
PubTator Score 79.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title