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Tbio
PCBD2
Pterin-4-alpha-carbinolamine dehydratase 2

Protein Summary
Description
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254908
  • ENSP00000254908
  • ENSG00000132570
  • ENST00000512783
  • ENSP00000421544

Symbol
  • DCOH2
  • DCOHM
  • PHS2
  • DCOH2
  • DCOHM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.81
cell type or tissue
0.74
virus perturbation
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
PCBD1
Tbio
Family:  Enzyme
Novelty:  0.01564376
p_int:  0.993021379
p_ni:  0.006978621
Score:  0.856
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.809122121
p_ni:  0.187758653
p_wrong:  0.003119226
Data Source:  BioPlex
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.777538281
p_ni:  0.222461442
p_wrong:  2.77e-7
Data Source:  BioPlex
DYRK1B
Tchem
Family:  Kinase
Novelty:  0.01960932
Score:  0.983
Data Source:  STRINGDB
QDPR
Tchem
Family:  Enzyme
Novelty:  0.00836889
Score:  0.953
Data Source:  STRINGDB
HNF1A
Tbio
Family:  TF
Novelty:  0.00101291
Score:  0.951
Data Source:  STRINGDB
TPH2
Tchem
Family:  Enzyme
Novelty:  0.00265377
Score:  0.926
Data Source:  STRINGDB
PAH
Tclin
Family:  Enzyme
Novelty:  0.00337068
Score:  0.923
Data Source:  STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
Score:  0.923
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
4
94.5
BMI-adjusted hip circumference
2
6
7
89.7
hip circumference
1
1
1
74.8
heel bone mineral density
2
2
2
72.3
IGF-1 measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
94.5
BMI-adjusted hip circumference
7
89.7
hip circumference
1
74.8
heel bone mineral density
2
72.3
IGF-1 measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pterin-4 alpha-carbinolamine dehydratase 2
VGNC:7098
745243
Macaque
pterin-4 alpha-carbinolamine dehydratase 2
713854
Mouse
MGI:1919812
72562
Rat
RGD:1590239
685729
Dog
pterin-4 alpha-carbinolamine dehydratase 2
VGNC:51756
609970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pterin-4 alpha-carbinolamine dehydratase 2
Macaque
pterin-4 alpha-carbinolamine dehydratase 2
Mouse
Rat
Dog
pterin-4 alpha-carbinolamine dehydratase 2
Publication Statistics
PubMed Score 7.09
PubMed score by year
PubTator Score 3.57
PubTator score by year
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Related Publications
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PMID
Year
Title