Tbio PCBD2 Pterin-4-alpha-carbinolamine dehydratase 2

Protein Summary

Description

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

Uniprot Accession IDs

• Q9H0N5
• Q8TD40
• PHS 2

Gene Name

• PCBD2

Ensembl ID

• ENST00000254908
• ENSP00000254908
• ENSG00000132570
• ENST00000512783
• ENSP00000421544

Symbol

• DCOH2
• DCOHM
• PHS2
• DCOH2
• DCOHM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.87
transcription factor binding site profile	0.81
cell type or tissue	0.74
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Lyase / Dehydratase / Pterin-4-alpha-carbinolamine Dehydratase 2

DTO Classes

Protein / Enzyme / Lyase / Dehydratase / Pterin-4-alpha-carbinolamine Dehydratase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

PCBD1

Tbio

Family:  Enzyme

Novelty:  0.01564376

p_int:  0.993021379

p_ni:  0.006978621

Score:  0.856

Data Source:  BioPlex,STRINGDB

LGALS1

Tchem

Novelty:  0.00106509

p_int:  0.809122121

p_ni:  0.187758653

p_wrong:  0.003119226

Data Source:  BioPlex

METAP2

Tchem

Family:  Enzyme

Novelty:  0.00570955

p_int:  0.777538281

p_ni:  0.222461442

p_wrong:  2.77e-7

Data Source:  BioPlex

DYRK1B

Tchem

Family:  Kinase

Novelty:  0.01960932

Score:  0.983

Data Source:  STRINGDB

QDPR

Tchem

Family:  Enzyme

Novelty:  0.00836889

Score:  0.953

Data Source:  STRINGDB

HNF1A

Tbio

Family:  TF

Novelty:  0.00101291

Score:  0.951

Data Source:  STRINGDB

TPH2

Tchem

Family:  Enzyme

Novelty:  0.00265377

Score:  0.926

Data Source:  STRINGDB

PAH

Tclin

Family:  Enzyme

Novelty:  0.00337068

Score:  0.923

Data Source:  STRINGDB

TPH1

Tclin

Family:  Enzyme

Novelty:  0.00098637

Score:  0.923

Data Source:  STRINGDB

TH

Tclin

Family:  Enzyme

Novelty:  0.00025719

Score:  0.923

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

KEGG (2)

PathwayCommons (1)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Folate biosynthesis	27 targets	path:hsa00790
KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Folate biosynthesis	27 targets	path:hsa00790
Metabolic pathways	1433 targets	path:hsa01100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (1)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
4-alpha-hydroxytetrahydrobiopterin dehydratase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
phenylalanine 4-monooxygenase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	4	4	4		94.5
BMI-adjusted hip circumference	EFO_0008039	2	6	7		89.7
hip circumference	EFO_0005093	1	1	1		74.8
heel bone mineral density	EFO_0009270	2	2	2		72.3
IGF-1 measurement	EFO_0004627	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	4		94.5
BMI-adjusted hip circumference	EFO_0008039	7		89.7
hip circumference	EFO_0005093	1		74.8
heel bone mineral density	EFO_0009270	2		72.3
IGF-1 measurement	EFO_0004627	1		49.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Lyase
Reference proteome
Tetrahydrobiopterin biosynthesis

GWAS Trait Find Similar Targets

No Header	No Header
anthropometric measurement
atrial fibrillation
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
colorectal cancer
heel bone mineral density
hip circumference
IGF-1 measurement
inflammatory bowel disease

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pterin-4 alpha-carbinolamine dehydratase 2	VGNC:7098	745243
Macaque	pterin-4 alpha-carbinolamine dehydratase 2		713854
Mouse	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	MGI:1919812	72562
Rat	pterin-4 alpha-carbinolamine dehydratase 2	RGD:1590239	685729
Dog	pterin-4 alpha-carbinolamine dehydratase 2	VGNC:51756	609970

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pterin-4 alpha-carbinolamine dehydratase 2
Macaque	pterin-4 alpha-carbinolamine dehydratase 2
Mouse	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Rat	pterin-4 alpha-carbinolamine dehydratase 2
Dog	pterin-4 alpha-carbinolamine dehydratase 2

Publication Statistics

PubMed Score 7.09

PubMed score by year

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PubTator Score 3.57

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title