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Tbio
PBXIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

Protein Summary
Description
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368463
  • ENSP00000357448
  • ENSG00000163346
  • ENST00000368465
  • ENSP00000357450

Symbol
  • HPIP
  • HPIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
ligand (protein) perturbation
0.83
small molecule perturbation
0.81
cell type or tissue
0.78
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.28   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.28   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
CCDC127
Tdark
Novelty:  1.49311359
p_int:  0.999999956
p_ni:  7e-9
p_wrong:  3.7e-8
Data Source:  BioPlex
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999996259
p_ni:  0.000003741
Data Source:  BioPlex
RDH14
Tdark
Family:  Enzyme
Novelty:  0.35816611
p_int:  0.999990301
p_ni:  0.000009699
Data Source:  BioPlex
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.999985559
p_ni:  0.000014441
Data Source:  BioPlex
TAPT1
Tbio
Novelty:  0.12057711
p_int:  0.999968068
p_ni:  0.000030326
p_wrong:  0.000001606
Data Source:  BioPlex
EXOG
Tbio
Family:  Enzyme
Novelty:  0.03588463
p_int:  0.999944514
p_ni:  0.000055486
Data Source:  BioPlex
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
p_int:  0.999919409
p_ni:  0.000080591
Data Source:  BioPlex
NBN
Tbio
Novelty:  0.00759456
p_int:  0.99989685
p_ni:  0.000103141
p_wrong:  9e-9
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999895062
p_ni:  0.000104938
Data Source:  BioPlex
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999893909
p_ni:  0.000105041
p_wrong:  0.00000105
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
7
18
96.8
appendicular lean mass
3
3
6
95.3
7
3
0
1.1
94.9
eosinophil count
3
2
3
93.2
waist-hip ratio
3
7
9
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
18
96.8
appendicular lean mass
6
95.3
0
1.1
94.9
eosinophil count
3
93.2
waist-hip ratio
9
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox interacting protein 1
VGNC:10497
458002
Macaque
PBX homeobox interacting protein 1
717036
Mouse
MGI:2441670
229534
Rat
RGD:1305180
310644
Dog
PBX homeobox interacting protein 1
VGNC:44290
480133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX homeobox interacting protein 1
Macaque
PBX homeobox interacting protein 1
Mouse
Rat
Dog
PBX homeobox interacting protein 1
Publication Statistics
PubMed Score 12.28
PubMed score by year
PubTator Score 29.90
PubTator score by year
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Related Publications
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PMID
Year
Title