PBX2
Pre-B-cell leukemia transcription factor 2
Protein Summary
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
- ENST00000375050
- ENSP00000364190
- ENSG00000204304
- ENST00000383270
- ENSP00000372757
- ENSG00000206315
- ENST00000420432
- ENSP00000410710
- ENSG00000236353
- ENST00000431537
- ENSP00000390009
- ENSG00000232005
- ENST00000433552
- ENSP00000391745
- ENSG00000224952
- ENST00000453487
- ENSP00000403948
- ENSG00000225987
- ENST00000453961
- ENSP00000397177
- ENSG00000237344
- G17
- G17
- HOX12
- PBX2MHC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
microRNA | 0.82 | ||
disease | 0.68 | ||
small molecule perturbation | 0.63 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70.35 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70.35 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (133)
MEIS2
Family: TF
Novelty: 0.01393828
p_int: 0.99999998
p_ni: 2.1e-8
Score: 0.956
Data Source: BioPlex,STRINGDB
PKNOX1
Family: TF
Novelty: 0.01063674
p_int: 0.999999796
p_ni: 1.92e-7
p_wrong: 1.2e-8
Score: 0.83
Data Source: BioPlex,STRINGDB
MAB21L1
Novelty: 0.07438538
p_int: 0.999999631
p_ni: 3.69e-7
Score: 0.846
Data Source: BioPlex,STRINGDB
LMX1B
Family: TF
Novelty: 0.00405645
p_int: 0.999994251
p_ni: 0.000005749
Score: 0.771
Data Source: BioPlex,STRINGDB
MAB21L2
Novelty: 0.05770595
p_int: 0.999942232
p_ni: 0.000057765
p_wrong: 2e-9
Score: 0.687
Data Source: BioPlex,STRINGDB
FAM222A
Novelty: 0.41466126
p_int: 0.999925618
p_ni: 0.000074382
Score: 0.696
Data Source: BioPlex,STRINGDB
C5orf24
Novelty: 3.95177775
p_int: 0.999637003
p_ni: 0.000362997
Score: 0.185
Data Source: BioPlex,STRINGDB
PBX4
Family: TF
Novelty: 0.09471693
p_int: 0.999569053
p_ni: 0.000378473
p_wrong: 0.000052475
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (5)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred by Curator (IC) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (539)
Items per page:
1 – 5 of 539
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
Items per page:
1 – 5 of 539
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | PBX homeobox 2 | VGNC:11143 | 462585 | |||||
Macaque | PBX homeobox 2 | 716239 | ||||||
Mouse | MGI:1341793 | 18515 | ||||||
Rat | RGD:1303084 | 406164 | ||||||
Dog | PBX homeobox 2 | VGNC:44287 | 607695 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | PBX homeobox 2 | |||||
Macaque | PBX homeobox 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | PBX homeobox 2 | |||||
Publication Statistics
PubMed Score 70.35
PubMed score by year
PubTator Score 60.93
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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