PBX2
Pre-B-cell leukemia transcription factor 2
Protein Summary
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
- ENST00000375050
- ENSP00000364190
- ENSG00000204304
- ENST00000383270
- ENSP00000372757
- ENSG00000206315
- ENST00000420432
- ENSP00000410710
- ENSG00000236353
- ENST00000431537
- ENSP00000390009
- ENSG00000232005
- ENST00000433552
- ENSP00000391745
- ENSG00000224952
- ENST00000453487
- ENSP00000403948
- ENSG00000225987
- ENST00000453961
- ENSP00000397177
- ENSG00000237344
- G17
- G17
- HOX12
- PBX2MHC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
microRNA | 0.82 | ||
disease | 0.68 | ||
small molecule perturbation | 0.63 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.51 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.51 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0