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Tbio
PBX2
Pre-B-cell leukemia transcription factor 2

Protein Summary
Description
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375050
  • ENSP00000364190
  • ENSG00000204304
  • ENST00000383270
  • ENSP00000372757
  • ENSG00000206315
  • ENST00000420432
  • ENSP00000410710
  • ENSG00000236353
  • ENST00000431537
  • ENSP00000390009
  • ENSG00000232005
  • ENST00000433552
  • ENSP00000391745
  • ENSG00000224952
  • ENST00000453487
  • ENSP00000403948
  • ENSG00000225987
  • ENST00000453961
  • ENSP00000397177
  • ENSG00000237344

Symbol
  • G17
  • G17
  • HOX12
  • PBX2MHC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
microRNA
0.82
disease
0.68
small molecule perturbation
0.63
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.51   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.51   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0