Tbio PBX1 Pre-B-cell leukemia transcription factor 1

Protein Summary

Description

Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Uniprot Accession IDs

• P40424
• B4DSC1
• F5H4U9
• Q5T488

Gene Name

• PBX1

Ensembl ID

• ENST00000367897
• ENSP00000356872
• ENSG00000185630
• ENST00000420696
• ENSP00000405890
• ENST00000627490
• ENSP00000485692

Symbol

• PRL
• CAKUHED

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.99
PubMedID	0.95
virus perturbation	0.92
biological process	0.9

Protein Classes

PANTHER Classes

Protein / ... / Homeodomain Transcription Factor / Pre-b-cell Leukemia Transcription Factor 1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Pre-b-cell Leukemia Transcription Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.55   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 338   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.55   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (240)

Explore Interacting Targets

1 – 10 of 240

• See Interactions on String-DB

PKNOX1

Tbio

Family:  TF

Novelty:  0.01063674

p_int:  0.999999845

p_ni:  1.55e-7

Score:  0.991

Data Source:  BioPlex,Reactome,STRINGDB

MEIS2

Tbio

Family:  TF

Novelty:  0.01393828

p_int:  0.999999486

p_ni:  5.14e-7

Score:  0.957

Data Source:  BioPlex,STRINGDB

MAB21L1

Tbio

Novelty:  0.07438538

p_int:  0.999896542

p_ni:  0.000103458

Score:  0.85

Data Source:  BioPlex,STRINGDB

FAM222A

Tdark

Novelty:  0.41466126

p_int:  0.999040769

p_ni:  0.000959231

Score:  0.828

Data Source:  BioPlex,STRINGDB

LMX1B

Tbio

Family:  TF

Novelty:  0.00405645

p_int:  0.998790429

p_ni:  0.001209563

p_wrong:  8e-9

Score:  0.822

Data Source:  BioPlex,STRINGDB

MAB21L2

Tbio

Novelty:  0.05770595

p_int:  0.998558768

p_ni:  0.001441232

Score:  0.702

Data Source:  BioPlex,STRINGDB

VWA5A

Tbio

Novelty:  0.0802354

p_int:  0.99806611

p_ni:  0.00193389

Score:  0.275

Data Source:  BioPlex,STRINGDB

C5orf24

Tdark

Novelty:  3.95177775

p_int:  0.993276965

p_ni:  0.006723035

Score:  0.373

Data Source:  BioPlex,STRINGDB

CCDC120

Tbio

Novelty:  0.48574876

p_int:  0.992458394

p_ni:  0.007541604

p_wrong:  1e-9

Score:  0.269

Data Source:  BioPlex,STRINGDB

MAGEA1

Tbio

Novelty:  0.00506874

p_int:  0.986460901

p_ni:  0.013539099

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (8)

KEGG (3)

PathwayCommons (1)

WikiPathways (4)

Activation of HOX genes during differentiation (R-HSA-5619507)

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5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	NOTCH3 Intracellular Domain Regulates Transcription	25 targets	R-HSA-9013508
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Developmental Biology	1055 targets	R-HSA-1266738
NOTCH3 Intracellular Domain Regulates Transcription	25 targets	R-HSA-9013508
Signal Transduction	2704 targets	R-HSA-162582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (7)

Components (4)

Processes (18)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	ProtInc
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	3	3		89.7
viral load	EFO_0010125	1	1	1		73.9
mean platelet volume	EFO_0004584	2	1	2		72.9
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	2		63.6
waist circumference	EFO_0004342	1	1	1		50.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	3		89.7
viral load	EFO_0010125	1		73.9
mean platelet volume	EFO_0004584	2		72.9
BMI-adjusted waist-hip ratio	EFO_0007788	2		63.6
waist circumference	EFO_0004342	1		50.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Activator
Alternative splicing
Chromosomal rearrangement
Complete proteome
Developmental protein
Differentiation
Disease mutation
DNA-binding
Homeobox

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
diastolic blood pressure
lymphocyte count
mathematical ability
mean platelet volume
mean reticulocyte volume
sex hormone-binding globulin measurement
viral load

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PBX homeobox 1	VGNC:11604	457474
Macaque	PBX homeobox 1		694416
Mouse	pre B cell leukemia homeobox 1	MGI:97495	18514
Rat	PBX homeobox 1	RGD:1308213	304947
Dog	PBX homeobox 1	VGNC:44286	488669

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PBX homeobox 1
Macaque	PBX homeobox 1
Mouse	pre B cell leukemia homeobox 1
Rat	PBX homeobox 1
Dog	PBX homeobox 1

Publication Statistics

PubMed Score 307.55

PubMed score by year

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PubTator Score 169.87

PubTator score by year

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Related Publications

Text Mined References (107)

GeneRif Annotations (67)

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PMID	Year	Title