Protein Summary
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
- ENST00000296302
- ENSP00000296302
- ENSG00000163939
- ENST00000337303
- ENSP00000338302
- ENST00000356770
- ENSP00000349213
- ENST00000394830
- ENSP00000378307
- ENST00000409057
- ENSP00000386593
- ENST00000409114
- ENSP00000386643
- ENST00000409767
- ENSP00000386601
- ENST00000410007
- ENSP00000386529
- ENST00000412587
- ENSP00000404579
- BAF180
- PB1
- PB1
- BAF180
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.88 | ||
virus perturbation | 0.88 | ||
kinase perturbation | 0.81 | ||
microRNA | 0.76 | ||
transcription factor | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.24 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 152 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.24 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 152 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (10)
Protein-Protein Interactions (150)
BCL7C
Novelty: 0.31203802
p_int: 0.999998684
p_ni: 0.000001316
Score: 0.832
Data Source: BioPlex,STRINGDB
SMARCC2
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999998385
p_ni: 0.000001615
Score: 0.999
Data Source: BioPlex,STRINGDB
SMARCB1
Novelty: 0.00116387
p_int: 0.999998322
p_ni: 0.000001678
Score: 0.995
Data Source: BioPlex,STRINGDB
BCL7A
Novelty: 0.07026394
p_int: 0.999980854
p_ni: 0.000019146
Score: 0.808
Data Source: BioPlex,STRINGDB
DPF3
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999965334
p_ni: 0.000034666
Score: 0.987
Data Source: BioPlex,STRINGDB
SMARCE1
Family: TF
Novelty: 0.01748089
p_int: 0.999926179
p_ni: 0.000073821
Score: 0.995
Data Source: BioPlex,STRINGDB
NUP50
Novelty: 0.03424725
p_int: 0.999910299
p_ni: 0.000089701
Score: 0.632
Data Source: BioPlex,STRINGDB
SMARCD1
Novelty: 0.03176642
p_int: 0.999866448
p_ni: 0.000133551
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (8)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RMTs methylate histone arginines | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RMTs methylate histone arginines | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (52)
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 14 | 21 | 42 | 97.9 | |||||
triglyceride measurement | 2 | 3 | 3 | 93 | |||||
high density lipoprotein cholesterol measurement | 5 | 5 | 7 | 91.9 | |||||
waist-hip ratio | 4 | 18 | 21 | 91.9 | |||||
adiponectin measurement | 3 | 3 | 3 | 89.1 | |||||
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 42 | 97.9 | |||||
triglyceride measurement | 3 | 93 | |||||
high density lipoprotein cholesterol measurement | 7 | 91.9 | |||||
waist-hip ratio | 21 | 91.9 | |||||
adiponectin measurement | 3 | 89.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | polybromo 1 | VGNC:2500 | 460430 | |||||
Macaque | polybromo 1 | 696361 | ||||||
Mouse | MGI:1923998 | 66923 | ||||||
Rat | RGD:1565549 | 306254 | ||||||
Dog | polybromo 1 | VGNC:44285 | 476593 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | polybromo 1 | |||||
Macaque | polybromo 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | polybromo 1 | |||||
Publication Statistics
PubMed Score 188.24
PubMed score by year
PubTator Score 483.58
PubTator score by year
Related Publications
Text Mined References (78)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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