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Tchem
PBRM1
Protein polybromo-1

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296302
  • ENSP00000296302
  • ENSG00000163939
  • ENST00000337303
  • ENSP00000338302
  • ENST00000356770
  • ENSP00000349213
  • ENST00000394830
  • ENSP00000378307
  • ENST00000409057
  • ENSP00000386593
  • ENST00000409114
  • ENSP00000386643
  • ENST00000409767
  • ENSP00000386601
  • ENST00000410007
  • ENSP00000386529
  • ENST00000412587
  • ENSP00000404579

Symbol
  • BAF180
  • PB1
  • PB1
  • BAF180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
virus perturbation
0.88
kinase perturbation
0.81
microRNA
0.76
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.24   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.24   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
CHEMBL2177300
Rendered image for CHEMBL2177300
CHEMBL3822689
Rendered image for CHEMBL3822689
PFI-3
Rendered image for PFI-3
CHEMBL3819245
Rendered image for CHEMBL3819245
PFI-3
Rendered image for PFI-3
CHEMBL3899245
Rendered image for CHEMBL3899245
CHEMBL3823524
Rendered image for CHEMBL3823524
CHEMBL3823132
Rendered image for CHEMBL3823132
CHEMBL3824067
Rendered image for CHEMBL3824067
CHEMBL3823055
Rendered image for CHEMBL3823055
Protein-Protein Interactions (150)
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999998684
p_ni:  0.000001316
Score:  0.832
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999998385
p_ni:  0.000001615
Score:  0.999
Data Source:  BioPlex,STRINGDB
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999998322
p_ni:  0.000001678
Score:  0.995
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999980854
p_ni:  0.000019146
Score:  0.808
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.999965334
p_ni:  0.000034666
Score:  0.987
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999926179
p_ni:  0.000073821
Score:  0.995
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999910299
p_ni:  0.000089701
Score:  0.632
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999866448
p_ni:  0.000133551
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.992390059
p_ni:  0.007609941
Data Source:  BioPlex
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.944417554
p_ni:  0.055582446
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
14
21
42
97.9
triglyceride measurement
2
3
3
93
high density lipoprotein cholesterol measurement
5
5
7
91.9
waist-hip ratio
4
18
21
91.9
adiponectin measurement
3
3
3
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
42
97.9
triglyceride measurement
3
93
high density lipoprotein cholesterol measurement
7
91.9
waist-hip ratio
21
91.9
adiponectin measurement
3
89.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polybromo 1
VGNC:2500
460430
Macaque
polybromo 1
696361
Mouse
MGI:1923998
66923
Rat
RGD:1565549
306254
Dog
polybromo 1
VGNC:44285
476593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polybromo 1
Macaque
polybromo 1
Mouse
Rat
Dog
polybromo 1
Publication Statistics
PubMed Score 188.24
PubMed score by year
PubTator Score 483.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title