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Tbio
PAXX
Protein PAXX

Protein Summary
Description
Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. The protein encoded by this gene plays a role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair. The encoded protein may function to stabilize the Ku70/Ku80 heterodimer to facilitate the assembly and maintain the stability of the NHEJ complex. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371620
  • ENSP00000360682
  • ENSG00000148362

Symbol
  • C9orf142
  • XLS
  • XLS
  • C9orf142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
p_int:  0.997104803
p_ni:  0.002893647
p_wrong:  0.00000155
Score:  0.204
Data Source:  BioPlex,STRINGDB
VASH1
Tbio
Novelty:  0.01093552
p_int:  0.99161982
p_ni:  0.008380098
p_wrong:  8.2e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
p_int:  0.985310072
p_ni:  0.007668248
p_wrong:  0.007021679
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.961473677
p_ni:  0.038525791
p_wrong:  5.32e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
NHEJ1
Tbio
Novelty:  0.00773499
Score:  0.978
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.977
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.976
Data Source:  STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
Score:  0.971
Data Source:  STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.966
Data Source:  STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
5
5
90
central corneal thickness
3
2
0
2.9
84
monocyte percentage of leukocytes
2
2
2
78.5
lymphocyte count
2
2
3
68.7
renal system measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
90
central corneal thickness
0
2.9
84
monocyte percentage of leukocytes
2
78.5
lymphocyte count
3
68.7
renal system measurement
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAXX, non-homologous end joining factor
VGNC:4634
748817
Macaque
PAXX, non-homologous end joining factor
707874
Mouse
MGI:2442831
227622
Dog
PAXX, non-homologous end joining factor
VGNC:44283
480670
Horse
PAXX, non-homologous end joining factor
VGNC:21180
100146303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAXX, non-homologous end joining factor
Macaque
PAXX, non-homologous end joining factor
Mouse
Dog
PAXX, non-homologous end joining factor
Horse
PAXX, non-homologous end joining factor
Publication Statistics
PubMed Score 42.82
PubMed score by year
PubTator Score 6.14
PubTator score by year
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Related Publications
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PMID
Year
Title