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Tbio
PAXIP1
PAX-interacting protein 1

Protein Summary
Description
Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397192
  • ENSP00000380376
  • ENSG00000157212
  • ENST00000404141
  • ENSP00000384048

Symbol
  • PAXIP1L
  • PTIP
  • PTIP
  • TNRC2
  • CAGF28
  • CAGF29
  • PACIP1
  • PAXIP1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.99
histone modification site profile
0.85
transcription factor binding site profile
0.72
cell type or tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.93   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.93   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (204)
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999843
p_ni:  1.57e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999999809
p_ni:  1.9e-7
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.999970101
p_ni:  0.000029859
p_wrong:  4e-8
Data Source:  BioPlex
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.996
Data Source:  Reactome,STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.993
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.992
Data Source:  STRINGDB
NCOA6
Tbio
Novelty:  0.00750424
Score:  0.991
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.99
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.99
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Activation of HOX genes during differentiation (R-HSA-5619507)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Double-Strand Break Repair
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAX interacting protein 1
VGNC:8719
463836
Macaque
PAX interacting protein 1
718279
Mouse
MGI:1890430
55982
Rat
RGD:1307547
311944
Dog
PAX interacting protein 1
VGNC:44282
482813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAX interacting protein 1
Macaque
PAX interacting protein 1
Mouse
Rat
Dog
PAX interacting protein 1
Publication Statistics
PubMed Score 63.93
PubMed score by year
PubTator Score 32.03
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title