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Tbio
PAX5
Paired box protein Pax-5

Protein Summary
Description
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358127
  • ENSP00000350844
  • ENSG00000196092
  • ENST00000377840
  • ENSP00000367071
  • ENST00000377847
  • ENSP00000367078
  • ENST00000377852
  • ENSP00000367083
  • ENST00000377853
  • ENSP00000367084
  • ENST00000414447
  • ENSP00000412188
  • ENST00000446742
  • ENSP00000404687
  • ENST00000520281
  • ENSP00000430773
  • ENST00000523493
  • ENSP00000431038

Symbol
  • ALL3
  • BSAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
biological term
0.84
cell type or tissue
0.81
molecular function
0.79
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 946.89   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 841   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 946.89   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 841   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0