PAX3
Paired box protein Pax-3
Protein Summary
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]
- ENST00000258387
- ENSP00000258387
- ENSG00000135903
- ENST00000336840
- ENSP00000338767
- ENST00000344493
- ENSP00000342092
- ENST00000350526
- ENSP00000343052
- ENST00000392069
- ENSP00000375921
- ENST00000392070
- ENSP00000375922
- ENST00000409551
- ENSP00000386750
- ENST00000409828
- ENSP00000386817
- HUP2
- WS1
- WS3
- CDHS
- HUP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.88 | ||
protein domain | 0.85 | ||
microRNA | 0.83 | ||
cell type or tissue | 0.8 | ||
PubMedID | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 750.98 (req: < 5)
Gene RIFs: 140 (req: <= 3)
Antibodies: 500 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 750.98 (req: >= 5)
Gene RIFs: 140 (req: > 3)
Antibodies: 500 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (189)
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999995642
p_ni: 9.3e-8
p_wrong: 0.000004265
Score: 0.173
Data Source: BioPlex,STRINGDB
NELL2
Family: Enzyme
Novelty: 0.03760438
p_int: 0.999858175
p_ni: 0.000003908
p_wrong: 0.000137917
Score: 0.237
Data Source: BioPlex,STRINGDB
SPIN1
Novelty: 0.00889909
p_int: 0.952767386
p_ni: 8.06e-7
p_wrong: 0.047231809
Score: 0.356
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (3)
KEGG (1)
PathwayCommons (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
HATs acetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (1)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 1 | 1 | 87.3 | |||||
facial morphology measurement | 2 | 5 | 7 | 85.1 | |||||
balding measurement | 1 | 2 | 2 | 81.3 | |||||
hair color | 1 | 3 | 0 | 1.1 | 72.6 | ||||
facial morphology | 1 | 1 | 1 | 66 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
synophrys measurement | 1 | 87.3 | |||||
facial morphology measurement | 7 | 85.1 | |||||
balding measurement | 2 | 81.3 | |||||
hair color | 0 | 1.1 | 72.6 | ||||
facial morphology | 1 | 66 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | paired box 3 | VGNC:2747 | 459971 | |||||
Macaque | paired box 3 | 705315 | ||||||
Mouse | MGI:97487 | 18505 | ||||||
Rat | RGD:620431 | 114502 | ||||||
Dog | paired box 3 | VGNC:44277 | 488544 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | paired box 3 | |||||
Macaque | paired box 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | paired box 3 | |||||
Publication Statistics
PubMed Score 750.98
PubMed score by year
PubTator Score 467.43
PubTator score by year
Related Publications
Text Mined References (206)
GeneRif Annotations (140)
Items per page:
0 of 0
PMID | Year | Title |
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