Tbio PATZ1 POZ-, AT hook-, and zinc finger-containing protein 1

Protein Summary

Description

Transcriptional repressor. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HBE1
• Q9HBE2
• Q9HBE3
• Q9P1A9
• Q9UDU0
• Q9Y529

Gene Name

• PATZ1

Ensembl ID

• ENST00000215919
• ENSP00000215919
• ENSG00000100105
• ENST00000266269
• ENSP00000266269
• ENST00000351933
• ENSP00000337520
• ENST00000405309
• ENSP00000384173

Symbol

• PATZ
• RIAZ
• ZBTB19
• ZNF278
• ZSG
• ZSG
• MAZR
• PATZ
• RIAZ
• ZBTB19
• ZNF278
• dJ400N23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor binding site profile	0.96
virus perturbation	0.95
virus	0.89
transcription factor	0.87

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.89   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.89   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0