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Tbio
PATJ
InaD-like protein

Protein Summary
Description
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371158
  • ENSP00000360200
  • ENSG00000132849
  • ENST00000484937
  • ENSP00000433669

Symbol
  • INADL
  • Cipp
  • INADL
  • hINADL
  • InaD-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.44   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.44   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
LIN7C
Tbio
Novelty:  0.06778878
p_int:  0.999999999
p_ni:  1e-9
Score:  0.755
Data Source:  BioPlex,STRINGDB
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.999999829
p_ni:  1.71e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
FAM124A
Tdark
Novelty:  1.51577847
p_int:  0.999971908
p_ni:  0.000028092
Data Source:  BioPlex
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.999952293
p_ni:  0.000047704
p_wrong:  2e-9
Score:  0.552
Data Source:  BioPlex,STRINGDB
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.962930197
p_ni:  0.037069628
p_wrong:  1.75e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.945626053
p_ni:  0.054373747
p_wrong:  2e-7
Score:  0.499
Data Source:  BioPlex,STRINGDB
CRB3
Tbio
Novelty:  0.05397064
Score:  0.978
Data Source:  Reactome,STRINGDB
CRB1
Tbio
Novelty:  0.00560299
Score:  0.921
Data Source:  STRINGDB
PLEKHG5
Tbio
Novelty:  0.01182841
Score:  0.866
Data Source:  STRINGDB
Pathways (7)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
2
6
88.6
daytime rest measurement
1
1
1
82.7
body height
1
1
1
71.3
comparative body size at age 10, self-reported
1
1
1
71
chronotype measurement
2
1
1
1.1
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
88.6
daytime rest measurement
1
82.7
body height
1
71.3
comparative body size at age 10, self-reported
1
71
chronotype measurement
1
1.1
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PATJ, crumbs cell polarity complex component
VGNC:8087
456900
Mouse
MGI:1277960
12695
Horse
PATJ, crumbs cell polarity complex component
VGNC:21173
100070486
Cow
PATJ, crumbs cell polarity complex component
VGNC:32592
536993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PATJ, crumbs cell polarity complex component
Mouse
Horse
PATJ, crumbs cell polarity complex component
Cow
PATJ, crumbs cell polarity complex component
Publication Statistics
PubMed Score 66.44
PubMed score by year
PubTator Score 46.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title