Protein Summary
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
- ENST00000371158
- ENSP00000360200
- ENSG00000132849
- ENST00000484937
- ENSP00000433669
- INADL
- Cipp
- INADL
- hINADL
- InaD-like
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.44 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.44 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (133)
LIN7C
Novelty: 0.06778878
p_int: 0.999999999
p_ni: 1e-9
Score: 0.755
Data Source: BioPlex,STRINGDB
MPP5
Novelty: 0.01707773
p_int: 0.999999993
p_ni: 7e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LIN7B
Novelty: 0.12689192
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.47
Data Source: BioPlex,STRINGDB
HOMER3
Novelty: 0.04408998
p_int: 0.999952293
p_ni: 0.000047704
p_wrong: 2e-9
Score: 0.552
Data Source: BioPlex,STRINGDB
RNF166
Novelty: 0.71460884
p_int: 0.962930197
p_ni: 0.037069628
p_wrong: 1.75e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
PCDHAC2
Novelty: 0.28397695
p_int: 0.945626053
p_ni: 0.054373747
p_wrong: 2e-7
Score: 0.499
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (7)
Reactome (4)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Components (10)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 6 | 2 | 6 | 88.6 | |||||
daytime rest measurement | 1 | 1 | 1 | 82.7 | |||||
body height | 1 | 1 | 1 | 71.3 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 71 | |||||
chronotype measurement | 2 | 1 | 1 | 1.1 | 70.9 | ||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 6 | 88.6 | |||||
daytime rest measurement | 1 | 82.7 | |||||
body height | 1 | 71.3 | |||||
comparative body size at age 10, self-reported | 1 | 71 | |||||
chronotype measurement | 1 | 1.1 | 70.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | PATJ, crumbs cell polarity complex component | VGNC:8087 | 456900 | |||||
Mouse | MGI:1277960 | 12695 | ||||||
Horse | PATJ, crumbs cell polarity complex component | VGNC:21173 | 100070486 | |||||
Cow | PATJ, crumbs cell polarity complex component | VGNC:32592 | 536993 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | PATJ, crumbs cell polarity complex component | |||||
Mouse | ||||||
Horse | PATJ, crumbs cell polarity complex component | |||||
Cow | PATJ, crumbs cell polarity complex component | |||||
Publication Statistics
PubMed Score 66.44
PubMed score by year
PubTator Score 46.23
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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