Tbio PATJ InaD-like protein

Protein Summary

Description

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NI35
• O15249
• O43742
• O60833
• Q5VUA5
• Q5VUA6
• Q5VUA7
• Q5VUA8
• Q5VUA9
• Q5VUB0
• Q8WU78
• Q9H3N9
• Inadl protein

Gene Name

• PATJ

Ensembl ID

• ENST00000371158
• ENSP00000360200
• ENSG00000132849
• ENST00000484937
• ENSP00000433669

Symbol

• INADL
• Cipp
• INADL
• hINADL
• InaD-like

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.44   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.44   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (133)

Explore Interacting Targets

1 – 10 of 133

• See Interactions on String-DB

LIN7C

Tbio

Novelty:  0.06778878

p_int:  0.999999999

p_ni:  1e-9

Score:  0.755

Data Source:  BioPlex,STRINGDB

MPP5

Tbio

Novelty:  0.01707773

p_int:  0.999999993

p_ni:  7e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

LIN7B

Tbio

Novelty:  0.12689192

p_int:  0.999999829

p_ni:  1.71e-7

Score:  0.47

Data Source:  BioPlex,STRINGDB

FAM124A

Tdark

Novelty:  1.51577847

p_int:  0.999971908

p_ni:  0.000028092

Data Source:  BioPlex

HOMER3

Tbio

Novelty:  0.04408998

p_int:  0.999952293

p_ni:  0.000047704

p_wrong:  2e-9

Score:  0.552

Data Source:  BioPlex,STRINGDB

RNF166

Tdark

Novelty:  0.71460884

p_int:  0.962930197

p_ni:  0.037069628

p_wrong:  1.75e-7

Score:  0.173

Data Source:  BioPlex,STRINGDB

PCDHAC2

Tdark

Novelty:  0.28397695

p_int:  0.945626053

p_ni:  0.054373747

p_wrong:  2e-7

Score:  0.499

Data Source:  BioPlex,STRINGDB

CRB3

Tbio

Novelty:  0.05397064

Score:  0.978

Data Source:  Reactome,STRINGDB

CRB1

Tbio

Novelty:  0.00560299

Score:  0.921

Data Source:  STRINGDB

PLEKHG5

Tbio

Novelty:  0.01182841

Score:  0.866

Data Source:  STRINGDB

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Downstream (1)

1 – 1 of 1

ITGB2

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Hippo signaling pathway

Pathways (7)

Reactome (4)

KEGG (3)

Cell junction organization (R-HSA-446728)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Tight junction interactions	30 targets	R-HSA-420029

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Tight junction interactions	30 targets	R-HSA-420029

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Components (10)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 10 of 10

GO Term	Evidence	Assigned by
bicellular tight junction	Inferred from Direct Assay (IDA)	MGI
cell junction	Inferred from Direct Assay (IDA)	HPA
centrosome	Inferred from Direct Assay (IDA)	HPA
cytosol	Inferred from Direct Assay (IDA)	HPA
microtubule organizing center	Inferred from Direct Assay (IDA)	HPA
perinuclear region of cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
plasma membrane	Traceable Author Statement (TAS)	Reactome
apical plasma membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
protein-containing complex	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6	2	6		88.6
daytime rest measurement	EFO_0007828	1	1	1		82.7
body height	EFO_0004339	1	1	1		71.3
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		71
chronotype measurement	EFO_0008328	2	1	1	1.1	70.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6		88.6
daytime rest measurement	EFO_0007828	1		82.7
body height	EFO_0004339	1		71.3
comparative body size at age 10, self-reported	EFO_0009819	1		71
chronotype measurement	EFO_0008328	1	1.1	70.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Membrane
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
autism spectrum disorder symptom
body fat percentage
body height
body mass index
C-reactive protein measurement
chronotype measurement
circadian rhythm
colorectal cancer
comparative body size at age 10, self-reported
daytime rest measurement

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PATJ, crumbs cell polarity complex component	VGNC:8087	456900
Mouse	PATJ, crumbs cell polarity complex component	MGI:1277960	12695
Horse	PATJ, crumbs cell polarity complex component	VGNC:21173	100070486
Cow	PATJ, crumbs cell polarity complex component	VGNC:32592	536993

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PATJ, crumbs cell polarity complex component
Mouse	PATJ, crumbs cell polarity complex component
Horse	PATJ, crumbs cell polarity complex component
Cow	PATJ, crumbs cell polarity complex component

Publication Statistics

PubMed Score 66.44

PubMed score by year

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PubTator Score 46.23

PubTator score by year

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Related Publications

Text Mined References (35)

GeneRif Annotations (10)

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PMID	Year	Title