Tchem PARP4 Poly [ADP-ribose] polymerase 4

Protein Summary

Description

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKK3
• O75903
• Q14682
• Q5QNZ9
• Q9H1M6
• PARP-4

Gene Name

• PARP4

Ensembl ID

• ENST00000381989
• ENSP00000371419
• ENSG00000102699

Symbol

• ADPRTL1
• KIAA0177
• PARPL
• PH5P
• p193
• ARTD4
• PARPL
• VPARP
• VWA5C
• PARP-4
• VAULT3
• ADPRTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.74
protein domain	0.73
histone modification site profile	0.71
virus	0.66
tissue sample	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3