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Tclin
PARP2
Poly [ADP-ribose] polymerase 2

Protein Summary
Description
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear pote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250416
  • ENSP00000250416
  • ENSG00000129484
  • ENST00000429687
  • ENSP00000392972

Symbol
  • ADPRT2
  • ADPRTL2
  • ARTD2
  • ADPRT2
  • PARP-2
  • ADPRTL2
  • ADPRTL3
  • pADPRT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
histone modification site profile
0.84
virus perturbation
0.76
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.08   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.08   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 200
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (200)
CHEMBL372303,CHEMBL4161122
Rendered image for CHEMBL372303,CHEMBL4161122
CHEMBL1086580
Rendered image for CHEMBL1086580
CHEMBL3740104
Rendered image for CHEMBL3740104
Talazoparib
Rendered image for Talazoparib
US9255106, S3
Rendered image for US9255106, S3
CHEMBL4096060
Rendered image for CHEMBL4096060
CHEMBL4078014
Rendered image for CHEMBL4078014
CHEMBL4097093
Rendered image for CHEMBL4097093
CHEMBL4075511
Rendered image for CHEMBL4075511
US9260440, 69
Rendered image for US9260440, 69
Protein-Protein Interactions (210)
RNF146
Tbio
Family:  Enzyme
Novelty:  0.05463359
p_int:  0.999997098
p_ni:  0.000002902
Score:  0.797
Data Source:  BioPlex,STRINGDB
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
p_int:  0.9999918
p_ni:  0.0000082
Score:  0.972
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999991005
p_ni:  0.000008995
Score:  0.612
Data Source:  BioPlex,STRINGDB
CHD1L
Tbio
Family:  Enzyme
Novelty:  0.00980287
p_int:  0.999982555
p_ni:  0.000017445
Score:  0.975
Data Source:  BioPlex,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.999977284
p_ni:  0.000022716
Score:  0.822
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999950601
p_ni:  0.000049397
p_wrong:  2e-9
Score:  0.326
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999949408
p_ni:  0.000050592
Score:  0.981
Data Source:  BioPlex,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.999935167
p_ni:  0.000064832
Score:  0.942
Data Source:  BioPlex,STRINGDB
C1orf174
Tdark
Novelty:  4.20172485
p_int:  0.999870608
p_ni:  0.000129392
Data Source:  BioPlex
MACROD1
Tchem
Family:  Enzyme
Novelty:  0.03610474
p_int:  0.999709369
p_ni:  0.000290631
Score:  0.752
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Name
Explore in Pharos
Explore in Source
Base Excision Repair
DNA Damage Recognition in GG-NER
DNA Double-Strand Break Repair
DNA Repair
Dual Incision in GG-NER
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase 2
VGNC:3346
465197
Macaque
poly(ADP-ribose) polymerase 2
701955
Mouse
MGI:1341112
11546
Rat
RGD:1310568
290027
Dog
poly(ADP-ribose) polymerase 2
VGNC:54219
475392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase 2
Macaque
poly(ADP-ribose) polymerase 2
Mouse
Rat
Dog
poly(ADP-ribose) polymerase 2
Publication Statistics
PubMed Score 181.08
PubMed score by year
PubTator Score 113.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title