Tclin PARP2 Poly [ADP-ribose] polymerase 2

Protein Summary

Description

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UGN5
• Q8TEU4
• Q9NUV2
• Q9UMR4
• Q9Y6C8
• PARP-2

Gene Name

• PARP2

Ensembl ID

• ENST00000250416
• ENSP00000250416
• ENSG00000129484
• ENST00000429687
• ENSP00000392972

Symbol

• ADPRT2
• ADPRTL2
• ARTD2
• ADPRT2
• PARP-2
• ADPRTL2
• ADPRTL3
• pADPRT-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.97
histone modification site profile	0.84
virus perturbation	0.76
tissue sample	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.74   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.74   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 239

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4