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Tchem
PARP16
Mono [ADP-ribose] polymerase PARP16

Protein Summary
Description
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261888
  • ENSP00000261888
  • ENSG00000138617
  • ENST00000444347
  • ENSP00000396118
  • ENST00000649807
  • ENSP00000496935

Symbol
  • ARTD15
  • C15orf30
  • ARTD15
  • pART15
  • C15orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
histone modification site profile
0.78
microRNA
0.72
disease perturbation
0.68
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (44)
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999936953
p_ni:  0.00005862
p_wrong:  0.000004428
Data Source:  BioPlex
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.999921321
p_ni:  0.000067727
p_wrong:  0.000010952
Data Source:  BioPlex
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.999731507
p_ni:  0.000268493
Data Source:  BioPlex
RAI14
Tbio
Novelty:  0.06291577
p_int:  0.999688757
p_ni:  0.000311243
Score:  0.204
Data Source:  BioPlex,STRINGDB
NEDD1
Tbio
Novelty:  0.03077131
p_int:  0.9985436
p_ni:  0.001456398
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.998337726
p_ni:  0.001662274
Score:  0.169
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.997033402
p_ni:  0.002966598
Data Source:  BioPlex
B3GALNT2
Tbio
Family:  Enzyme
Novelty:  0.08266178
p_int:  0.992806799
p_ni:  0.007193201
Score:  0.188
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.972754979
p_ni:  0.02724488
p_wrong:  1.41e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.962806659
p_ni:  0.03719334
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
5
46.9
left atrial function
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
5
46.9
left atrial function
1
27.3
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 16
VGNC:3533
748071
Macaque
poly(ADP-ribose) polymerase family member 16
709140
Mouse
MGI:2446133
214424
Rat
RGD:1306243
315760
Dog
poly(ADP-ribose) polymerase family member 16
610816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 16
Macaque
poly(ADP-ribose) polymerase family member 16
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 16
Publication Statistics
PubMed Score 11.67
PubMed score by year
PubTator Score 39.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title