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Tchem
PARP14
Poly [ADP-ribose] polymerase 14

Protein Summary
Description
ADP-ribosyltransferase (PubMed:16061477, PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependent transcription (By similarity). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000474629
  • ENSP00000418194
  • ENSG00000173193

Symbol
  • BAL2
  • KIAA1268
  • BAL2
  • ARTD8
  • pART8
  • PARP-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.91
cell line
0.69
PubMedID
0.68
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (18)
CHEMBL4089522
Rendered image for CHEMBL4089522
CHEMBL4068366
Rendered image for CHEMBL4068366
CHEMBL4104503
Rendered image for CHEMBL4104503
CHEMBL4074448
Rendered image for CHEMBL4074448
CHEMBL4087082
Rendered image for CHEMBL4087082
CHEMBL4079213
Rendered image for CHEMBL4079213
CHEMBL4085694
Rendered image for CHEMBL4085694
CHEMBL4104938
Rendered image for CHEMBL4104938
CHEMBL4084742
Rendered image for CHEMBL4084742
CHEMBL4226482
Rendered image for CHEMBL4226482
Protein-Protein Interactions (74)
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.982
Data Source:  STRINGDB
DTX3L
Tbio
Family:  Enzyme
Novelty:  0.0622833
Score:  0.981
Data Source:  STRINGDB
PARP9
Tbio
Family:  Enzyme
Novelty:  0.02702134
Score:  0.963
Data Source:  STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.885
Data Source:  STRINGDB
RNF213
Tbio
Family:  Enzyme
Novelty:  0.00588778
Score:  0.88
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.814
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.763
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.732
Data Source:  STRINGDB
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
Score:  0.724
Data Source:  STRINGDB
IRGM
Tbio
Family:  Enzyme
Novelty:  0.0065731
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
78.1
calcium measurement
1
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
78.1
calcium measurement
2
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 14
VGNC:2496
460634
Macaque
poly(ADP-ribose) polymerase family member 14
715591
Mouse
MGI:1919489
547253
Rat
RGD:1310490
303903
Dog
poly(ADP-ribose) polymerase family member 14
VGNC:53082
608688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 14
Macaque
poly(ADP-ribose) polymerase family member 14
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 14
Publication Statistics
PubMed Score 60.52
PubMed score by year
PubTator Score 223.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title