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Tchem
PARP12
Poly [ADP-ribose] polymerase 12

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (76)
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.999945525
p_ni:  0.000054475
Data Source:  BioPlex
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.999684542
p_ni:  0.00022912
p_wrong:  0.000086338
Score:  0.538
Data Source:  BioPlex,STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
p_int:  0.998023847
p_ni:  0.001963499
p_wrong:  0.000012654
Score:  0.197
Data Source:  BioPlex,STRINGDB
MKRN2
Tbio
Family:  Enzyme
Novelty:  0.14061051
p_int:  0.988298437
p_ni:  0.011701533
p_wrong:  2.9e-8
Score:  0.395
Data Source:  BioPlex,STRINGDB
RNF114
Tbio
Family:  Enzyme
Novelty:  0.06758257
p_int:  0.987384483
p_ni:  0.012615517
Score:  0.694
Data Source:  BioPlex,STRINGDB
PARP9
Tbio
Family:  Enzyme
Novelty:  0.02702134
Score:  0.907
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.828
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.824
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.816
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
74.3
4
3
3
1.1
59.7
platelet count
1
1
1
59.5
myeloid white cell count
1
1
1
54.4
monocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
74.3
3
1.1
59.7
platelet count
1
59.5
myeloid white cell count
1
54.4
monocyte count
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 12
VGNC:4456
463776
Macaque
poly(ADP-ribose) polymerase family member 12
711660
Mouse
MGI:2143990
243771
Rat
RGD:1308628
362343
Dog
poly(ADP-ribose) polymerase family member 12
VGNC:51818
482770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 12
Macaque
poly(ADP-ribose) polymerase family member 12
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 12
Publication Statistics
PubMed Score 10.52
PubMed score by year
PubTator Score 21.04
PubTator score by year
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Related Publications
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PMID
Year
Title