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Tbio
PARP11
Poly [ADP-ribose] polymerase 11

Protein Summary
Description
Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228820
  • ENSP00000228820
  • ENSG00000111224
  • ENST00000416739
  • ENSP00000392392
  • ENST00000427057
  • ENSP00000397058
  • ENST00000447133
  • ENSP00000405385

Symbol
  • C12orf6
  • ARTD11
  • MIB006
  • C12orf6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.84
microRNA
0.69
transcription factor binding site profile
0.6
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.999890182
p_ni:  0.000107041
p_wrong:  0.000002777
Score:  0.787
Data Source:  BioPlex,STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
p_int:  0.996635725
p_ni:  0.003364097
p_wrong:  1.78e-7
Score:  0.622
Data Source:  BioPlex,STRINGDB
RNF114
Tbio
Family:  Enzyme
Novelty:  0.06758257
p_int:  0.985191913
p_ni:  0.014808087
Score:  0.831
Data Source:  BioPlex,STRINGDB
CRLF3
Tbio
Novelty:  0.17318857
Score:  0.707
Data Source:  STRINGDB
KIAA2013
Tdark
Novelty:  0.4705158
Score:  0.697
Data Source:  STRINGDB
PPP1R26
Tdark
Family:  Enzyme
Novelty:  0.21786867
Score:  0.693
Data Source:  STRINGDB
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
Score:  0.692
Data Source:  STRINGDB
OTUD4
Tbio
Novelty:  0.17121119
Score:  0.675
Data Source:  STRINGDB
GM2A
Tbio
Novelty:  0.00574276
Score:  0.674
Data Source:  STRINGDB
RCC2
Tbio
Novelty:  0.01806322
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granule cell layer dentate gyrus volume
1
1
0
3.9
40.7
hippocampal CA4 volume
1
1
0
3.3
37.6
hippocampal volume
1
1
0
35.6
35
hippocampus molecular layer volume
1
1
0
6.5
33.1
mean corpuscular volume
1
1
1
13
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granule cell layer dentate gyrus volume
0
3.9
40.7
hippocampal CA4 volume
0
3.3
37.6
hippocampal volume
0
35.6
35
hippocampus molecular layer volume
0
6.5
33.1
mean corpuscular volume
1
13
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 11
VGNC:8610
466921
Macaque
poly(ADP-ribose) polymerase family member 11
721828
Mouse
MGI:2141505
101187
Rat
RGD:1561791
500323
Dog
poly(ADP-ribose) polymerase family member 11
477722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 11
Macaque
poly(ADP-ribose) polymerase family member 11
Mouse
Rat
Dog
poly(ADP-ribose) polymerase family member 11
Publication Statistics
PubMed Score 6.43
PubMed score by year
PubTator Score 4.18
PubTator score by year
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Related Publications
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PMID
Year
Title