Tchem PARP10 Poly [ADP-ribose] polymerase 10

Protein Summary

Description

May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q53GL7
• Q8N2I0
• Q8WV05
• Q96CH7
• Q96K72
• PARP-10

Gene Name

• PARP10

Ensembl ID

• ENST00000313028
• ENSP00000325618
• ENSG00000178685

Symbol

• ARTD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological process	0.78
tissue sample	0.77
cell type or tissue	0.67
cell line	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.98   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.98   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1