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Tbio
PARN
Poly(A)-specific ribonuclease PARN

Protein Summary
Description
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:151751 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341484
  • ENSP00000345456
  • ENSG00000140694
  • ENST00000420015
  • ENSP00000410525
  • ENST00000437198
  • ENSP00000387911
  • ENST00000539279
  • ENSP00000444381
  • ENST00000615183
  • ENSP00000478668
  • ENSG00000274829
  • ENST00000618929
  • ENSP00000484279
  • ENST00000631868
  • ENSP00000488554
  • ENST00000634004
  • ENSP00000487634

Symbol
  • DAN
  • DAN
  • DKCB6
  • PFBMFT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
disease perturbation
0.93
virus perturbation
0.92
transcription factor binding site profile
0.85
co-expressed gene
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.33   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.33   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0