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Tbio
PARN
Poly(A)-specific ribonuclease PARN

Protein Summary
Description
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:151751 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341484
  • ENSP00000345456
  • ENSG00000140694
  • ENST00000420015
  • ENSP00000410525
  • ENST00000437198
  • ENSP00000387911
  • ENST00000539279
  • ENSP00000444381
  • ENST00000615183
  • ENSP00000478668
  • ENSG00000274829
  • ENST00000618929
  • ENSP00000484279
  • ENST00000631868
  • ENSP00000488554
  • ENST00000634004
  • ENSP00000487634

Symbol
  • DAN
  • DAN
  • DKCB6
  • PFBMFT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
disease perturbation
0.93
virus perturbation
0.92
transcription factor binding site profile
0.85
co-expressed gene
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.06   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.06   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
B9D2
Tbio
Novelty:  0.11310836
p_int:  0.999998332
p_ni:  0.000001668
Data Source:  BioPlex
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.999997793
p_ni:  0.000001602
p_wrong:  6.05e-7
Score:  0.642
Data Source:  BioPlex,STRINGDB
LGI2
Tbio
Novelty:  0.09195527
p_int:  0.999997287
p_ni:  0.000002713
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.999987655
p_ni:  0.000012345
Data Source:  BioPlex
TEAD4
Tchem
Family:  TF
Novelty:  0.0114979
p_int:  0.996919166
p_ni:  0.003080758
p_wrong:  7.5e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.994430252
p_ni:  0.005569727
p_wrong:  2.1e-8
Data Source:  BioPlex
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.982152739
p_ni:  0.017846996
p_wrong:  2.64e-7
Data Source:  BioPlex
TSR1
Tbio
Novelty:  0.01639069
p_int:  0.952161085
p_ni:  0.032138909
p_wrong:  0.015700006
Score:  0.765
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.938788375
p_ni:  0.060599191
p_wrong:  0.000612434
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.912048126
p_ni:  0.049570495
p_wrong:  0.038381378
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (40)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
55.2
mathematical ability
1
1
1
52
1
1
0
2.2
38.8
diastolic blood pressure
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
55.2
mathematical ability
1
52
0
2.2
38.8
diastolic blood pressure
1
5.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A)-specific ribonuclease
VGNC:13784
453936
Macaque
poly(A)-specific ribonuclease
712984
Mouse
MGI:1921358
74108
Rat
RGD:1565449
360464
Dog
poly(A)-specific ribonuclease
VGNC:53535
479839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A)-specific ribonuclease
Macaque
poly(A)-specific ribonuclease
Mouse
Rat
Dog
poly(A)-specific ribonuclease
Publication Statistics
PubMed Score 136.06
PubMed score by year
PubTator Score 70.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title