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Tbio
PARK7
Protein/nucleic acid deglycase DJ-1

Protein Summary
Description
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338639
  • ENSP00000340278
  • ENSG00000116288
  • ENST00000377488
  • ENSP00000366708
  • ENST00000377491
  • ENSP00000366711
  • ENST00000493373
  • ENSP00000465404
  • ENST00000493678
  • ENSP00000418770

Symbol
  • DJ1
  • DJ-1
  • GATD2
  • HEL-S-67p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
kinase perturbation
1
molecular function
1
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.92   (req: < 5)
Gene RIFs: 312   (req: <= 3)
Antibodies: 808   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.92   (req: >= 5)
Gene RIFs: 312   (req: > 3)
Antibodies: 808   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0