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Tbio
PARD3
Partitioning defective 3 homolog

Protein Summary
Description
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340077
  • ENSP00000341844
  • ENSG00000148498
  • ENST00000346874
  • ENSP00000340591
  • ENST00000350537
  • ENSP00000311986
  • ENST00000374776
  • ENSP00000363908
  • ENST00000374788
  • ENSP00000363920
  • ENST00000374789
  • ENSP00000363921
  • ENST00000374794
  • ENSP00000363926
  • ENST00000545260
  • ENSP00000440857
  • ENST00000545693
  • ENSP00000443147

Symbol
  • PAR3
  • PAR3A
  • Baz
  • ASIP
  • PAR3
  • PARD-3
  • PARD3A
  • SE2-5T2
  • PPP1R118
  • SE2-5L16
  • SE2-5LT1
  • PAR3alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.88
biological process
0.87
drug perturbation
0.87
PubMedID
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.46   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.46   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0