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Tbio
PAPOLG
Poly(A) polymerase gamma

Protein Summary
Description
Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238714
  • ENSP00000238714
  • ENSG00000115421

Symbol
  • PAP2
  • PAPG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.74
protein domain
0.73
microRNA
0.72
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.99998069
p_ni:  0.000008904
p_wrong:  0.000010406
Data Source:  BioPlex
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999957634
p_ni:  0.000042366
Score:  0.477
Data Source:  BioPlex,STRINGDB
LRSAM1
Tbio
Family:  Enzyme
Novelty:  0.04083443
p_int:  0.998675589
p_ni:  0.001324405
p_wrong:  7e-9
Data Source:  BioPlex
RPS6KA1
Tchem
Family:  Kinase
Novelty:  0.00178073
p_int:  0.998218185
p_ni:  0.001781815
Data Source:  BioPlex
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.888
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.876
Data Source:  STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
Score:  0.86
Data Source:  STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.852
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.852
Data Source:  STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.816
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.2
84.6
4
2
3
1.1
77.8
1
1
0
1.1
61.4
psoriasis vulgaris
1
1
0
1.2
53.3
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
84.6
3
1.1
77.8
0
1.1
61.4
psoriasis vulgaris
0
1.2
53.3
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) polymerase gamma
VGNC:10734
459259
Macaque
poly(A) polymerase gamma
717781
Mouse
MGI:2442119
216578
Rat
RGD:1310337
305586
Dog
poly(A) polymerase gamma
VGNC:54531
481382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) polymerase gamma
Macaque
poly(A) polymerase gamma
Mouse
Rat
Dog
poly(A) polymerase gamma
Publication Statistics
PubMed Score 40.57
PubMed score by year
PubTator Score 8.03
PubTator score by year
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Related Publications
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PMID
Year
Title