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Tchem
PAOX
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Protein Summary
Description
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278060
  • ENSP00000278060
  • ENSG00000148832
  • ENST00000356306
  • ENSP00000348654
  • ENST00000357296
  • ENSP00000349847
  • ENST00000476834
  • ENSP00000432737
  • ENST00000480071
  • ENSP00000435514
  • ENST00000483211
  • ENSP00000434550
  • ENST00000529585
  • ENSP00000432517

Symbol
  • PAO
  • PAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.7
transcription factor perturbation
0.68
cellular component
0.67
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.1   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.1   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (8)
Protein-Protein Interactions (89)
SAT1
Tbio
Family:  Enzyme
Novelty:  0.0022456
Score:  0.99
Data Source:  STRINGDB
SAT2
Tbio
Family:  Enzyme
Novelty:  0.10019856
Score:  0.979
Data Source:  STRINGDB
DDO
Tchem
Family:  Enzyme
Novelty:  0.02519366
Score:  0.956
Data Source:  STRINGDB
DAO
Tchem
Family:  Enzyme
Novelty:  0.00414923
Score:  0.955
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.953
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.937
Data Source:  STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
Score:  0.934
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.932
Data Source:  STRINGDB
PEX10
Tbio
Novelty:  0.0174463
Score:  0.931
Data Source:  STRINGDB
NUDT7
Tdark
Family:  Enzyme
Novelty:  0.05817561
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Amine Oxidase reactions (R-HSA-140179)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biological oxidations
Reactome
Interconversion of polyamines
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biological oxidations
Interconversion of polyamines
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
67.3
blood metabolite measurement
1
1
1
57.8
longevity
1
1
0
3.5
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
67.3
blood metabolite measurement
1
57.8
longevity
0
3.5
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837]
Mouse
MGI:1916983
212503
Rat
RGD:1561125
293589
Horse
polyamine oxidase
VGNC:21149
100629322
Cow
polyamine oxidase
VGNC:32570
282639
Species
Name
OMA
EggNOG
Inparanoid
Macaque
polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837]
Mouse
Rat
Horse
polyamine oxidase
Cow
polyamine oxidase
Publication Statistics
PubMed Score 86.10
PubMed score by year
PubTator Score 161.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title