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Tchem
PAOX
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Protein Summary
Description
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278060
  • ENSP00000278060
  • ENSG00000148832
  • ENST00000356306
  • ENSP00000348654
  • ENST00000357296
  • ENSP00000349847
  • ENST00000476834
  • ENSP00000432737
  • ENST00000480071
  • ENSP00000435514
  • ENST00000483211
  • ENSP00000434550
  • ENST00000529585
  • ENSP00000432517

Symbol
  • PAO
  • PAO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.7
transcription factor perturbation
0.68
cellular component
0.67
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0