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Tbio
PANX3
Pannexin-3

Protein Summary
Description
Structural component of the gap junctions and the hemichannels. The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284288
  • ENSP00000284288
  • ENSG00000154143

Symbol
  • PX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.61
cell line
0.57
cell type or tissue
0.53
gene perturbation
0.53
cellular component
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.12   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.12   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
GJA1
Tbio
Novelty:  0.00021332
Score:  0.833
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.795
Data Source:  STRINGDB
GJD2
Tbio
Novelty:  0.00263903
Score:  0.768
Data Source:  STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.761
Data Source:  STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.757
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.753
Data Source:  STRINGDB
GJB6
Tbio
Novelty:  0.00119317
Score:  0.687
Data Source:  STRINGDB
CALHM1
Tbio
Family:  IC
Novelty:  0.01742976
Score:  0.682
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.677
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
60.2
1
1
0
1.1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
60.2
0
1.1
4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pannexin 3
VGNC:3076
738559
Mouse
MGI:1918881
208098
Rat
RGD:735137
315567
Horse
pannexin 3
VGNC:21148
100064156
Cow
pannexin 3
VGNC:32569
538977
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pannexin 3
Mouse
Rat
Horse
pannexin 3
Cow
pannexin 3
Publication Statistics
PubMed Score 133.12
PubMed score by year
PubTator Score 26.84
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title