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Tbio
PANX2
Pannexin-2

Protein Summary
Description
Structural component of the gap junctions and the hemichannels. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000159647
  • ENSP00000159647
  • ENSG00000073150
  • ENST00000395842
  • ENSP00000379183

Symbol
  • PX2
  • hPANX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
histone modification site profile
0.54
cellular component
0.51
cell line
0.5
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.26   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.26   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
PANX1
Tbio
Family:  IC
Novelty:  0.00159814
Score:  0.93
Data Source:  Reactome,STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.802
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.785
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.774
Data Source:  STRINGDB
GJD2
Tbio
Novelty:  0.00263903
Score:  0.772
Data Source:  STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.771
Data Source:  STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.725
Data Source:  STRINGDB
GJB6
Tbio
Novelty:  0.00119317
Score:  0.698
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.684
Data Source:  STRINGDB
P2RX7
Tchem
Family:  IC
Novelty:  0.00090502
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Electric Transmission Across Gap Junctions (R-HSA-112303)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Electric Transmission Across Gap Junctions
Reactome
Neuronal System
Reactome
Transmission across Electrical Synapses
Name
Explore in Pharos
Explore in Source
Electric Transmission Across Gap Junctions
Neuronal System
Transmission across Electrical Synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4
6
90.6
platelet crit
2
3
4
89.5
hematological measurement
1
1
1
88.5
mitochondrial DNA measurement
1
2
2
86
plasminogen activator inhibitor 1 measurement
1
1
0
421.8
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
90.6
platelet crit
4
89.5
hematological measurement
1
88.5
mitochondrial DNA measurement
2
86
plasminogen activator inhibitor 1 measurement
0
421.8
74.7
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pannexin 2
VGNC:5291
470248
Macaque
pannexin 2
720613
Mouse
MGI:1890615
406218
Rat
RGD:735191
362979
Dog
pannexin 2
VGNC:44255
481195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pannexin 2
Macaque
pannexin 2
Mouse
Rat
Dog
pannexin 2
Publication Statistics
PubMed Score 180.26
PubMed score by year
PubTator Score 36.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title