Tbio PANK2 Pantothenate kinase 2, mitochondrial

Protein Summary

Description

May be the master regulator of the CoA biosynthesis. This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BZ23
• B1AK33
• B2Z3X0
• D3DVZ0
• Q5T7I2
• Q5T7I4
• Q7RTX5
• Q8N7Q4
• Q8TCR5
• Q9BYW5
• Q9HAF2
• hPanK2

Gene Name

• PANK2

Ensembl ID

• ENST00000316562
• ENSP00000313377
• ENSG00000125779
• ENST00000497424
• ENSP00000417609
• ENST00000610179
• ENSP00000477429
• ENST00000621507
• ENSP00000481523

Symbol

• C20orf48
• HSS
• HARP
• PKAN
• NBIA1
• C20orf48

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
transcription factor binding site profile	0.81
cell type or tissue	0.79
biological process	0.75
transcription factor	0.66

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Type Ii Pantothenate Kinase Family / Pantothenate Kinase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.76   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.76   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0