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Tdark
PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

Protein Summary
Description
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.77
cell type or tissue
0.72
histone modification site profile
0.72
microRNA
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
PAN2
Tbio
Family:  Enzyme
Novelty:  0.1195117
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.999999992
p_ni:  8e-9
p_wrong:  1e-9
Data Source:  BioPlex
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999999969
p_ni:  3e-8
p_wrong:  1e-9
Score:  0.247
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999999783
p_ni:  2.17e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.99061932
p_ni:  0.000074661
p_wrong:  0.009306018
Score:  0.156
Data Source:  BioPlex,STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.97
Data Source:  STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.924
Data Source:  STRINGDB
EIF4B
Tbio
Novelty:  0.00665561
Score:  0.915
Data Source:  STRINGDB
EIF4A3
Tchem
Novelty:  0.00981496
Score:  0.91
Data Source:  STRINGDB
EIF4A2
Tbio
Novelty:  0.00298045
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
5
5
99.3
monocyte percentage of leukocytes
2
6
6
99
leukocyte count
2
4
4
95.1
neutrophil count
2
4
4
94.3
lymphocyte percentage of leukocytes
2
2
2
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
99.3
monocyte percentage of leukocytes
6
99
leukocyte count
4
95.1
neutrophil count
4
94.3
lymphocyte percentage of leukocytes
2
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) specific ribonuclease subunit PAN3
VGNC:7299
736229
Macaque
PAN3 poly(A) specific ribonuclease subunit
711494
Mouse
MGI:1919837
72587
Rat
RGD:1590880
360760
Dog
PAN3 poly(A) specific ribonuclease subunit
486024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) specific ribonuclease subunit PAN3
Macaque
PAN3 poly(A) specific ribonuclease subunit
Mouse
Rat
Dog
PAN3 poly(A) specific ribonuclease subunit
Publication Statistics
PubMed Score 0.66
PubMed score by year
PubTator Score 11.30
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title