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Tbio
PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Protein Summary
Description
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257931
  • ENSP00000257931
  • ENSG00000135473
  • ENST00000425394
  • ENSP00000401721
  • ENST00000440411
  • ENSP00000388231
  • ENST00000548043
  • ENSP00000449861
  • ENST00000610546
  • ENSP00000481859

Symbol
  • KIAA0710
  • USP52
  • USP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.92
transcription factor binding site profile
0.91
histone modification site profile
0.88
transcription factor
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
PAN3
Tdark
Family:  Kinase
Novelty:  3.36673347
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.999999895
p_ni:  1e-7
p_wrong:  4e-9
Data Source:  BioPlex
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999999187
p_ni:  2.69e-7
p_wrong:  5.45e-7
Score:  0.291
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999998742
p_ni:  1.08e-7
p_wrong:  0.00000115
Score:  0.58
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999537432
p_ni:  0.000416738
p_wrong:  0.00004583
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.996397878
p_ni:  0.003525857
p_wrong:  0.000076265
Data Source:  BioPlex
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.972
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.923
Data Source:  STRINGDB
EIF4A1
Tchem
Novelty:  0.00269994
Score:  0.921
Data Source:  STRINGDB
EIF4A2
Tbio
Novelty:  0.00298045
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
8
9
99.5
5
4
0
1.4
84.7
1
2
0
1.5
66.6
psoriasis vulgaris
1
1
0
1.4
63.7
lymphocyte percentage of leukocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
99.5
0
1.4
84.7
0
1.5
66.6
psoriasis vulgaris
0
1.4
63.7
lymphocyte percentage of leukocytes
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PAN2 poly(A) specific ribonuclease subunit
712478
Mouse
MGI:1918984
103135
Rat
RGD:1303301
408200
Dog
poly(A) specific ribonuclease subunit PAN2
VGNC:54530
474404
Horse
PAN2 poly(A) specific ribonuclease subunit
100052396
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PAN2 poly(A) specific ribonuclease subunit
Mouse
Rat
Dog
poly(A) specific ribonuclease subunit PAN2
Horse
PAN2 poly(A) specific ribonuclease subunit
Publication Statistics
PubMed Score 9.20
PubMed score by year
PubTator Score 75.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title