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Tchem
PAM
Peptidyl-glycine alpha-amidating monooxygenase

Protein Summary
Description
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304400
  • ENSP00000306100
  • ENSG00000145730
  • ENST00000346918
  • ENSP00000282992
  • ENST00000348126
  • ENSP00000314638
  • ENST00000438793
  • ENSP00000396493
  • ENST00000455264
  • ENSP00000403461

Symbol
  • PAL
  • PHM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.91
molecular function
0.88
virus perturbation
0.85
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (60)
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.999558303
p_ni:  0.000441697
Data Source:  BioPlex
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
p_int:  0.999069217
p_ni:  0.000930779
p_wrong:  4e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.995449832
p_ni:  0.004550167
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.98382012
p_ni:  0.01617988
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.971681938
p_ni:  0.02831806
p_wrong:  2e-9
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.949417874
p_ni:  0.050582124
p_wrong:  2e-9
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.902562978
p_ni:  0.097437022
Score:  0.202
Data Source:  BioPlex,STRINGDB
SERPINA6
Tchem
Novelty:  0.00055116
p_int:  0.799880681
p_ni:  0.200109358
p_wrong:  0.000009961
Score:  0.345
Data Source:  BioPlex,STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.772537966
p_ni:  0.227462033
Data Source:  BioPlex
ART3
Tbio
Family:  Enzyme
Novelty:  0.02783085
p_int:  0.759011932
p_ni:  0.240988048
p_wrong:  2e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
1
1.1
94
balding measurement
1
2
2
81
appendicular lean mass
3
1
3
65.6
Drugs used in diabetes use measurement
1
1
1
64.4
sleep duration
2
2
1
1
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
94
balding measurement
2
81
appendicular lean mass
3
65.6
Drugs used in diabetes use measurement
1
64.4
sleep duration
1
1
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylglycine alpha-amidating monooxygenase
VGNC:4116
461974
Macaque
peptidylglycine alpha-amidating monooxygenase
707733
Mouse
MGI:97475
18484
Rat
RGD:3252
25508
Dog
peptidylglycine alpha-amidating monooxygenase
VGNC:44250
479145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylglycine alpha-amidating monooxygenase
Macaque
peptidylglycine alpha-amidating monooxygenase
Mouse
Rat
Dog
peptidylglycine alpha-amidating monooxygenase
Publication Statistics
PubMed Score 244.42
PubMed score by year
PubTator Score 707.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title