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Tbio
PALLD
Palladin

Protein Summary
Description
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261509
  • ENSP00000261509
  • ENSG00000129116
  • ENST00000505667
  • ENSP00000425556
  • ENST00000507735
  • ENSP00000424016
  • ENST00000512127
  • ENSP00000426947

Symbol
  • KIAA0992
  • MYN
  • PNCA1
  • CGI151
  • SIH002
  • CGI-151
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.99
ligand (protein) perturbation
0.96
PubMedID
0.91
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.68   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.68   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999999357
p_ni:  6.43e-7
Score:  0.695
Data Source:  BioPlex,STRINGDB
GRPEL1
Tbio
Novelty:  0.00185346
p_int:  0.999998797
p_ni:  0.000001202
p_wrong:  1e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.999982074
p_ni:  0.000017924
p_wrong:  2e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999976109
p_ni:  0.000023887
p_wrong:  3e-9
Data Source:  BioPlex
PFN2
Tbio
Novelty:  0.00605366
p_int:  0.999953612
p_ni:  0.000046387
p_wrong:  1e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.999907709
p_ni:  0.00009084
p_wrong:  0.000001451
Score:  0.215
Data Source:  BioPlex,STRINGDB
TAS2R50
Tchem
Family:  GPCR
Novelty:  0.15747063
Score:  0.902
Data Source:  STRINGDB
OR13G1
Tdark
Family:  oGPCR
Novelty:  0.63690138
Score:  0.902
Data Source:  STRINGDB
ROS1
Tclin
Family:  Kinase
Novelty:  0.00151582
Score:  0.804
Data Source:  STRINGDB
FSCN1
Tchem
Novelty:  0.00221877
Score:  0.747
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
4
71.1
pulse pressure measurement
1
1
1
66.4
electrocardiography
1
1
1
27.9
IGF-1 measurement
1
1
1
22.8
systolic blood pressure
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
71.1
pulse pressure measurement
1
66.4
electrocardiography
1
27.9
IGF-1 measurement
1
22.8
systolic blood pressure
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
palladin, cytoskeletal associated protein
VGNC:2073
739749
Macaque
palladin, cytoskeletal associated protein
693824
Mouse
MGI:1919583
72333
Dog
palladin, cytoskeletal associated protein
VGNC:44247
477351
Horse
palladin, cytoskeletal associated protein
VGNC:21142
100061451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
palladin, cytoskeletal associated protein
Macaque
palladin, cytoskeletal associated protein
Mouse
Dog
palladin, cytoskeletal associated protein
Horse
palladin, cytoskeletal associated protein
Publication Statistics
PubMed Score 143.68
PubMed score by year
PubTator Score 123.20
PubTator score by year
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Related Publications
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PMID
Year
Title